Yao Xiyang, Ma Junwei, Li Haiying, Shen Haitao, Lu Xiaojun, Chen Gang
1 Department of Neurosurgery and Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, China.
2 Department of Neurosurgery, Suzhou Kowloon Hospital Affiliated with Shanghai Jiao Tong University, Suzhou, China.
J Int Med Res. 2017 Feb;45(1):11-21. doi: 10.1177/0300060516671600. Epub 2017 Jan 12.
Background We evaluated the safety and efficiency of flow diverters (FDs) in treating small intracranial aneurysms (IAs). Materials and Methods We reviewed the literature published in PubMed and EMBASE. R for Project software was used to calculate the complete aneurysm occlusion rates, procedure-related neurologic mortality, procedure-related neurologic morbidity and procedure-related permanent morbidity. Results Ten observational studies were included in this analysis. The complete aneurysm occlusion rate was 84.23% (80.34%-87.76%), the procedure-related neurologic mortality was 0.87% (0.29%-1.74%), the procedure-related neurologic morbidity rate was 5.22% (3.62%-7.1%), the intracerebral haemorrhage rate was 1.42% (0.64%-2.49%), the ischemic rate was 2.35% (1.31%-3.68%), the subarachnoid haemorrhage rate was 0.03% (0%-0.32%) and the procedure-related permanent morbidity was 2.41% (0.81%-4.83%). Conclusions Treatment of small IAs with FDs may be correlated with high complete occlusion rates and low complication rates. Future long-term follow-up randomized trials will determine the optimal treatment for small IAs.
我们评估了血流导向装置（FDs）治疗小型颅内动脉瘤（IAs）的安全性和有效性。
我们回顾了在PubMed和EMBASE上发表的文献。使用R for Project软件计算完全动脉瘤闭塞率、与手术相关的神经死亡率、与手术相关的神经发病率以及与手术相关的永久性发病率。
本分析纳入了10项观察性研究。完全动脉瘤闭塞率为84.23%（80.34%-87.76%），与手术相关的神经死亡率为0.87%（0.29%-1.74%），与手术相关的神经发病率为5.22%（3.62%-7.1%），脑出血率为1.42%（0.64%-2.49%），缺血率为2.35%（1.31%-3.68%），蛛网膜下腔出血率为0.03%（0%-0.32%），与手术相关的永久性发病率为2.41%（0.81%-4.83%）。
使用FDs治疗小型IAs可能与高完全闭塞率和低并发症率相关。未来的长期随访随机试验将确定小型IAs的最佳治疗方法。
