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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Eisenhofer G, Goldstein D S, Stull R W, Gold P W, Keiser H R, Kopin I J

Intramural Research Program, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland 20892.

Clin Exp Pharmacol Physiol. 1987 Apr;14(4):337-41. doi: 10.1111/j.1440-1681.1987.tb00980.x.

The pituitary-adrenocortical, sympathoadrenomedullary and renin-angiotensin-aldosterone systems contribute to circulatory and metabolic homeostasis during stress. One possible site of co-ordination of these systems is the beta-adrenoceptor. 2. To determine whether circulating beta-adrenoceptor agonists can act hormonally to stimulate these systems simultaneously, plasma concentrations of corticotrophin (ACTH), noradrenaline, adrenaline and plasma renin activity were measured during graded intravenous infusions of isoprenaline in 20 people. 3. Administration of isoprenaline caused dose-related increases in noradrenaline (94% at the highest dose) and renin activity (189%), but decreases in ACTH (25%) and adrenaline (20%), findings inconsistent with simultaneous activation of these systems by circulating beta-adrenoceptor agonists.

垂体 - 肾上腺皮质、交感 - 肾上腺髓质和肾素 - 血管紧张素 - 醛固酮系统在应激过程中有助于维持循环和代谢稳态。这些系统的一个可能协调位点是β - 肾上腺素能受体。2. 为了确定循环中的β - 肾上腺素能受体激动剂是否能作为激素同时刺激这些系统，在20名受试者中静脉输注不同剂量的异丙肾上腺素期间，测量了促肾上腺皮质激素（ACTH）、去甲肾上腺素、肾上腺素的血浆浓度以及血浆肾素活性。3. 给予异丙肾上腺素导致去甲肾上腺素（最高剂量时增加94%）和肾素活性（增加189%）呈剂量依赖性升高，但ACTH（降低25%）和肾上腺素（降低20%）降低，这些结果与循环中的β - 肾上腺素能受体激动剂同时激活这些系统不一致。

Eisenhofer G, Goldstein D S, Stull R W, Gold P W, Keiser H R, Kopin I J

Intramural Research Program, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland 20892.

Clin Exp Pharmacol Physiol. 1987 Apr;14(4):337-41. doi: 10.1111/j.1440-1681.1987.tb00980.x.

The pituitary-adrenocortical, sympathoadrenomedullary and renin-angiotensin-aldosterone systems contribute to circulatory and metabolic homeostasis during stress. One possible site of co-ordination of these systems is the beta-adrenoceptor. 2. To determine whether circulating beta-adrenoceptor agonists can act hormonally to stimulate these systems simultaneously, plasma concentrations of corticotrophin (ACTH), noradrenaline, adrenaline and plasma renin activity were measured during graded intravenous infusions of isoprenaline in 20 people. 3. Administration of isoprenaline caused dose-related increases in noradrenaline (94% at the highest dose) and renin activity (189%), but decreases in ACTH (25%) and adrenaline (20%), findings inconsistent with simultaneous activation of these systems by circulating beta-adrenoceptor agonists.

垂体 - 肾上腺皮质、交感 - 肾上腺髓质和肾素 - 血管紧张素 - 醛固酮系统在应激过程中有助于维持循环和代谢稳态。这些系统的一个可能协调位点是β - 肾上腺素能受体。2. 为了确定循环中的β - 肾上腺素能受体激动剂是否能作为激素同时刺激这些系统，在20名受试者中静脉输注不同剂量的异丙肾上腺素期间，测量了促肾上腺皮质激素（ACTH）、去甲肾上腺素、肾上腺素的血浆浓度以及血浆肾素活性。3. 给予异丙肾上腺素导致去甲肾上腺素（最高剂量时增加94%）和肾素活性（增加189%）呈剂量依赖性升高，但ACTH（降低25%）和肾上腺素（降低20%）降低，这些结果与循环中的β - 肾上腺素能受体激动剂同时激活这些系统不一致。