单次注射可卡因可快速诱导伏隔核壳部的多巴胺致敏。
Rapid induction of dopamine sensitization in the nucleus accumbens shell induced by a single injection of cocaine.
作者信息
Singer Bryan F, Bryan Myranda A, Popov Pavlo, Robinson Terry E, Aragona Brandon J
机构信息
Biopsychology Area, Department of Psychology, University of Michigan, 530 Church Street, East Hall, Ann Arbor, MI 48109, USA.
Biopsychology Area, Department of Psychology, University of Michigan, 530 Church Street, East Hall, Ann Arbor, MI 48109, USA.
出版信息
Behav Brain Res. 2017 May 1;324:66-70. doi: 10.1016/j.bbr.2017.02.018. Epub 2017 Feb 14.
Repeated intermittent exposure to cocaine results in the neurochemical sensitization of dopamine (DA) transmission within the nucleus accumbens (NAc). Indeed, the excitability of DA neurons in the ventral tegmental area (VTA) is enhanced within hours of initial psychostimulant exposure. However, it is not known if this is accompanied by a comparably rapid change in the ability of cocaine to increase extracellular DA concentrations in the ventral striatum. To address this question we used fast-scan cyclic voltammetry (FSCV) in awake-behaving rats to measure DA responses in the NAc shell following an initial intravenous cocaine injection, and then again 2-h later. Both injections quickly elevated DA levels in the NAc shell, but the second cocaine infusion produced a greater effect than the first, indicating sensitization. This suggests that a single injection of cocaine induces sensitization-related plasticity very rapidly within the mesolimbic DA system.
反复间歇性接触可卡因会导致伏隔核（NAc）内多巴胺（DA）传递的神经化学敏化。事实上，在初次接触精神兴奋剂后的数小时内，腹侧被盖区（VTA）中DA神经元的兴奋性就会增强。然而，目前尚不清楚这是否伴随着可卡因增加腹侧纹状体细胞外DA浓度的能力发生同样快速的变化。为了解决这个问题，我们在清醒行为的大鼠中使用快速扫描循环伏安法（FSCV）来测量初次静脉注射可卡因后以及2小时后伏隔核壳中的DA反应。两次注射均迅速提高了伏隔核壳中的DA水平，但第二次注射可卡因产生的效果比第一次更大，表明出现了敏化现象。这表明单次注射可卡因会在中脑边缘DA系统内非常迅速地诱导与敏化相关的可塑性变化。
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