可卡因诱导的谷氨酸传递神经适应：对渴望和成瘾的潜在治疗靶点。
Cocaine-induced neuroadaptations in glutamate transmission: potential therapeutic targets for craving and addiction.
机构信息
Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
出版信息
Ann N Y Acad Sci. 2010 Feb;1187:35-75. doi: 10.1111/j.1749-6632.2009.05144.x.
Abstract
A growing body of evidence indicates that repeated exposure to cocaine leads to profound changes in glutamate transmission in limbic nuclei, particularly the nucleus accumbens. This review focuses on preclinical studies of cocaine-induced behavioral plasticity, including behavioral sensitization, self-administration, and the reinstatement of cocaine seeking. Behavioral, pharmacological, neurochemical, electrophysiological, biochemical, and molecular biological changes associated with cocaine-induced plasticity in glutamate systems are reviewed. The ultimate goal of these lines of research is to identify novel targets for the development of therapies for cocaine craving and addiction. Therefore, we also outline the progress and prospects of glutamate modulators for the treatment of cocaine addiction.
摘要
越来越多的证据表明，反复接触可卡因会导致边缘核（尤其是伏隔核）中谷氨酸传递的深刻变化。这篇综述重点介绍了可卡因引起的行为可塑性的临床前研究，包括行为敏感化、自我给药和可卡因寻求的恢复。本文综述了与可卡因诱导的谷氨酸系统可塑性相关的行为、药理学、神经化学、电生理学、生物化学和分子生物学变化。这些研究的最终目标是确定开发可卡因渴望和成瘾治疗方法的新靶点。因此，我们还概述了谷氨酸调节剂治疗可卡因成瘾的进展和前景。
相似文献
1
Cocaine-induced neuroadaptations in glutamate transmission: potential therapeutic targets for craving and addiction.
Ann N Y Acad Sci. 2010 Feb;1187:35-75. doi: 10.1111/j.1749-6632.2009.05144.x.
2
Glutamate: the new frontier in pharmacotherapy for cocaine addiction.
CNS Neurol Disord Drug Targets. 2008 Nov;7(5):482-91. doi: 10.2174/187152708786927868.
3
Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine.
Nat Neurosci. 2001 Dec;4(12):1217-23. doi: 10.1038/nn757.
4
Glutamate transmission in the nucleus accumbens mediates relapse in cocaine addiction.
J Neurosci. 2000 Aug 1;20(15):RC89. doi: 10.1523/JNEUROSCI.20-15-j0006.2000.
5
Cocaine sensitization and craving: differing roles for dopamine and glutamate in the nucleus accumbens.
J Addict Dis. 2001;20(3):43-54. doi: 10.1300/J069v20n03_05.
6
Silent Synapse-Based Circuitry Remodeling in Drug Addiction.
Int J Neuropsychopharmacol. 2016 Apr 29;19(5). doi: 10.1093/ijnp/pyv136. Print 2016 May.
7
Neuroadaptations in the cellular and postsynaptic group 1 metabotropic glutamate receptor mGluR5 and Homer proteins following extinction of cocaine self-administration.
Neurosci Lett. 2009 Mar 13;452(2):167-71. doi: 10.1016/j.neulet.2008.12.028. Epub 2008 Dec 24.
8
Anatomy and pharmacology of cocaine priming-induced reinstatement of drug seeking.
Eur J Pharmacol. 2005 Dec 5;526(1-3):65-76. doi: 10.1016/j.ejphar.2005.09.068.
9
Accumbal neurons that are activated during cocaine self-administration are spared from inhibitory effects of repeated cocaine self-administration.
Neuropsychopharmacology. 2007 May;32(5):1141-58. doi: 10.1038/sj.npp.1301203. Epub 2006 Oct 4.
10
CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking.
Nat Neurosci. 2008 Mar;11(3):344-53. doi: 10.1038/nn2054. Epub 2008 Feb 17.
引用本文的文献
1
Is Topiramate Helpful in the Management of Cocaine Use-Related Psychiatric Comorbidities?
Cureus. 2025 Jul 14;17(7):e87935. doi: 10.7759/cureus.87935. eCollection 2025 Jul.
2
Astroglial CB Reveal Sex-Specific Synaptic Effects of Amphetamine.
Glia. 2025 Aug;73(8):1673-1691. doi: 10.1002/glia.70026. Epub 2025 Apr 28.
3
Crystallin Alpha B Inhibits Cocaine-Induced Conditioned Place Preference via the Modulation of Dopaminergic Neurotransmission.
Addict Biol. 2025 Mar;30(3):e70028. doi: 10.1111/adb.70028.
4
Positive allosteric modulation of glutamate transporter reduces cocaine-induced locomotion and expression of cocaine conditioned place preference in rats.
Eur J Pharmacol. 2024 Dec 5;984:177017. doi: 10.1016/j.ejphar.2024.177017. Epub 2024 Sep 28.
5
Sex-specific effects of chronic stress prior to cocaine exposure on cue- vs drug-induced relapse after prolonged abstinence.
Behav Brain Res. 2024 Oct 2;474:115197. doi: 10.1016/j.bbr.2024.115197. Epub 2024 Aug 14.
6
A single-nucleus transcriptomic atlas of medium spiny neurons in the rat nucleus accumbens.
Sci Rep. 2024 Aug 6;14(1):18258. doi: 10.1038/s41598-024-69255-0.
7
Glutamate-Mediated Excitotoxicity in the Pathogenesis and Treatment of Neurodevelopmental and Adult Mental Disorders.
Int J Mol Sci. 2024 Jun 13;25(12):6521. doi: 10.3390/ijms25126521.
8
Exercise Influences the Brain's Metabolic Response to Chronic Cocaine Exposure in Male Rats.
J Pers Med. 2024 May 9;14(5):500. doi: 10.3390/jpm14050500.
9
Impaired striatal glutamate/GABA regulation in violent offenders with antisocial personality disorder and psychopathy.
Mol Psychiatry. 2024 Jun;29(6):1824-1832. doi: 10.1038/s41380-024-02437-4. Epub 2024 Feb 7.
10
Intrinsic Functional Connectivity between the Anterior Insular and Retrosplenial Cortex as a Moderator and Consequence of Cocaine Self-Administration in Rats.
J Neurosci. 2024 Feb 14;44(7):e1452232023. doi: 10.1523/JNEUROSCI.1452-23.2023.
本文引用的文献
1
Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seeking.
Behav Brain Res. 2009 Sep 14;202(2):238-44. doi: 10.1016/j.bbr.2009.03.039. Epub 2009 Apr 5.
2
D-cycloserine accelerates the extinction of cocaine-induced conditioned place preference in C57bL/c mice.
Behav Brain Res. 2009 May 16;199(2):345-9. doi: 10.1016/j.bbr.2008.12.025. Epub 2008 Dec 30.
3
D-cycloserine potentiates the reconsolidation of cocaine-associated memories.
Learn Mem. 2009 Jan 7;16(1):82-5. doi: 10.1101/lm.1186609. Print 2009 Jan.
4
N-Acetylcysteine reverses cocaine-induced metaplasticity.
Nat Neurosci. 2009 Feb;12(2):182-9. doi: 10.1038/nn.2250. Epub 2009 Jan 11.
5
The preferential dopamine D3 receptor antagonist S33138 inhibits cocaine reward and cocaine-triggered relapse to drug-seeking behavior in rats.
Neuropharmacology. 2009 Mar;56(4):752-60. doi: 10.1016/j.neuropharm.2008.12.007.
6
Glutamate: the new frontier in pharmacotherapy for cocaine addiction.
CNS Neurol Disord Drug Targets. 2008 Nov;7(5):482-91. doi: 10.2174/187152708786927868.
7
Neuroadaptations in the cellular and postsynaptic group 1 metabotropic glutamate receptor mGluR5 and Homer proteins following extinction of cocaine self-administration.
Neurosci Lett. 2009 Mar 13;452(2):167-71. doi: 10.1016/j.neulet.2008.12.028. Epub 2008 Dec 24.
8
Behavioral sensitization to cocaine is associated with increased glutamate receptor trafficking to the postsynaptic density after extended withdrawal period.
Neuroscience. 2009 Mar 3;159(1):414-26. doi: 10.1016/j.neuroscience.2008.10.027. Epub 2008 Nov 1.
9
The role of cystine-glutamate exchange in nicotine dependence in rats and humans.
Biol Psychiatry. 2009 May 15;65(10):841-5. doi: 10.1016/j.biopsych.2008.10.040. Epub 2008 Dec 21.
10
Sex differences in basal and cocaine-induced alterations in PKA and CREB proteins in the nucleus accumbens.
Psychopharmacology (Berl). 2009 Apr;203(3):641-50. doi: 10.1007/s00213-008-1411-5. Epub 2008 Dec 4.
Zotero 插件