University College London Medical School, London, UK.
Adv Exp Med Biol. 2017;1051:1-6. doi: 10.1007/5584_2017_12.
In this Introduction to the series of papers that follow about purinergic receptors, there is a brief history of the discovery of purinergic signalling, the identity of purinoceptors and the current recognition of P1, P2X and P2Y subtypes. An account of key functions mediated by purinoceptors follows, including examples of both short-term and long-term (trophic) signalling and a table showing the selective agonists and antagonists for the purinoceptor subtypes. References to evolution and roles of purinoceptors in pathological conditions are also presented.
在接下来的关于嘌呤能受体的系列论文的介绍中，简要回顾了嘌呤能信号的发现历史、嘌呤能受体的特性以及当前对 P1、P2X 和 P2Y 亚型的认识。接下来介绍了嘌呤能受体介导的关键功能，包括短期和长期（营养）信号的例子，以及一个显示嘌呤能受体亚型的选择性激动剂和拮抗剂的表格。还介绍了嘌呤能受体在进化和病理条件中的作用的参考文献。
