Sarowitz B N, Davis G J, Kim S
Department of Surgery, Red Bank Veterinary Hospital, Tinton Falls, NJ 07724, USA.
J Small Anim Pract. 2017 Mar;58(3):146-153. doi: 10.1111/jsap.12624. Epub 2017 Feb 22.
To describe the long-term outcomes and prognostic factors associated with curative-intent surgery for oral tumours in a large series of dogs.
Retrospective review of records for dogs with oral tumours treated with curative-intent surgery. Data collected included signalment, weight, surgical procedure, lymph node staging results, computed tomography results, tumour size, histopathology results including margin evaluation, complications, adjunctive therapies, local recurrence or metastasis, date and cause of death and owner satisfaction.
Median cause-specific survival was shortest for malignant melanoma (206 days) and osteosarcoma (209 days). Local recurrence rate was highest for fibrosarcoma (54·2%) and distant metastatic rate was highest for malignant melanoma (30%). Curative-intent surgery resulted in complete surgical margins in 85·2% of cases.
Results suggest tumour type, completeness of excision, tumour size, and age may affect disease-free interval and cause-specific survival. Fibrosarcoma had a higher risk of recurrence compared to other tumour types.
描述大量犬口腔肿瘤根治性手术的长期预后及预后因素。
对接受根治性手术治疗的犬口腔肿瘤病例记录进行回顾性分析。收集的数据包括特征、体重、手术过程、淋巴结分期结果、计算机断层扫描结果、肿瘤大小、组织病理学结果（包括切缘评估）、并发症、辅助治疗、局部复发或转移、死亡日期和原因以及主人满意度。
恶性黑色素瘤（206天）和骨肉瘤（209天）的特定病因中位生存期最短。纤维肉瘤的局部复发率最高（54.2%），恶性黑色素瘤的远处转移率最高（30%）。根治性手术在85.2%的病例中实现了完整的手术切缘。
结果表明肿瘤类型、切除完整性、肿瘤大小和年龄可能影响无病生存期和特定病因生存期。与其他肿瘤类型相比，纤维肉瘤的复发风险更高。
