Institute of Physics, University of Silesia, Uniwersytecka 4, 40-007 Katowice, Poland.
Silesian Center for Education and Interdisciplinary Research, 75 Pulku Piechoty 1A, 41-500 Chorzow, Poland.
Sci Rep. 2017 Feb 22;7:43091. doi: 10.1038/srep43091.
Glass is an ultraviscous liquid that ceases to flow on a laboratory timescale but continues to relax on a geological timescale. Quintessentially, it has become hopeless for humans to explore the equilibrium behavior of glass, although the technology of glass making witness a remarkable advance. In this work, we propose a novel thermodynamic path to prepare a high density amorphous state of matter (carvedilol dihydrogen phosphate) using high pressure. In addition, we provide the impeccable experimental evidence of heterogeneous nature of secondary β-relaxation and probe its properties to understand the various aspects of pressure densified glass, such as dynamics, packing and disorder. These features are expected to provide new horizons to glass preparation and functional response to pharmaceutical applications.
玻璃是一种超粘性液体，在实验室时间尺度上停止流动，但在地质时间尺度上继续松弛。从本质上讲，人类已经无法探索玻璃的平衡行为，尽管玻璃制造技术取得了显著的进步。在这项工作中，我们提出了一种使用高压制备高密度非晶态物质（卡维地洛二氢磷酸盐）的新热力学途径。此外，我们还提供了关于二次β弛豫异质性质的无可挑剔的实验证据，并对其性质进行了探测，以了解高压致密玻璃的各个方面，如动力学、堆积和无序。这些特性有望为玻璃制备和药物应用的功能响应提供新的视野。
