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[大肠杆菌K-12的环磷酸腺苷受体蛋白可能是噬菌体λ晚期启动子的阻遏物]

[cAMP acceptor protein of Escherichia coli K-12 may be the repressor of the late promoter of bacteriophage lambda].

作者信息

Gol'denberg D S

出版信息

Genetika. 1987 Aug;23(8):1360-5.

PMID:2822536
Abstract

By computer analysis of the lambda phage DNA putative cAMP-CAP binding site has been found. This site (44506-AcgTGTGAccgcatTCAAAaT-44486) is located 40 bp upstream to the late PR' promoter. The sequence denoted is located on the coding DNA strand, similar to the cAMP-CAP binding sites in all four genes known to be subject to cAMP-CAP repression. It is suggested that cAMP-CAP can serve as a repressor of the phage lambda late promoter PR'. Such repression can arrest the expression of late lambda genes and in this way increase the frequency of lysogenization.

摘要

通过计算机分析，发现了λ噬菌体DNA的假定cAMP - CAP结合位点。该位点（44506 - AcgTGTGAccgcatTCAAAaT - 44486）位于晚期PR'启动子上游40 bp处。所标记的序列位于编码DNA链上，类似于已知受cAMP - CAP抑制的所有四个基因中的cAMP - CAP结合位点。有人提出，cAMP - CAP可作为噬菌体λ晚期启动子PR'的阻遏物。这种抑制作用可阻止λ晚期基因的表达，从而提高溶原化频率。

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