Wolpert Katherine, Szadkowski Matthew, Miescier Michael, Hewes Hilary A
From the Department of Pediatrics and.
Division of Pediatric Emergency Medicine, University of Utah, Salt Lake City, UT.
Pediatr Emerg Care. 2019 Apr;35(4):e70-e71. doi: 10.1097/PEC.0000000000001083.
Vitamin K plays an integral role in the clotting cascade. Deficiency, specifically in vulnerable neonates with insufficient stores, can lead to spontaneous bleeding and devastating effects. In this case, we report a young infant with late-onset vitamin K deficiency bleeding who did not receive vitamin K prophylaxis after birth. Initially presenting with bruising and fussiness, the patient was later found to have intracerebral hemorrhage with midline shift and uncal herniation. The infant was not a surgical candidate and died shortly thereafter. Laboratory studies confirmed the diagnosis of late-onset vitamin K deficiency bleeding as the cause of hemorrhage and death.
维生素K在凝血级联反应中起着不可或缺的作用。缺乏维生素K，尤其是对于体内储存不足的脆弱新生儿来说，可能会导致自发性出血并产生严重后果。在此病例中，我们报告了一名迟发性维生素K缺乏性出血的幼儿，其出生后未接受维生素K预防治疗。该患儿最初表现为瘀伤和烦躁不安，随后被发现发生了脑出血并伴有中线移位和颞叶钩回疝。该婴儿不适合进行手术，此后不久便死亡。实验室检查证实迟发性维生素K缺乏性出血是出血和死亡的原因。
