Milan Aroha Sanchez, Campmany Ana Cristina Calpena, Naveros Beatriz Clares
Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona. Spain.
Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Granada University, P.O. Box: 18071 (Campus of Cartuja St. s/n), Granada. Spain.
Curr Drug Metab. 2017;18(5):437-453. doi: 10.2174/1389200218666170222145908.
Melatonin is emerging as a promising therapeutic agent, mainly due to its role as antioxidant. Substantial evidences show that melatonin is potentially effective in a variety of diseases as cancer, inflammation and neurodegenerative diseases. The excellent antioxidant capacity with pharmacokinetics characteristics and the emerging search for new pharmaceutical nanotechnology based systems, make it particularly attractive to elaborate nanoplatforms based on melatonin for biomedical or cosmetic dermal applications. Different nanosystems for dermal delivery have been investigated.
This review focuses on nanocarrier production strategies, dermal melatonin application and delivery advances in vivo and in vitro. Equally, future perspectives of this assisted melatonin delivery have also been discussed.
In the current review, we have revised relevant articles of the available literature using the major scientific databases.
One hundred and thirteen papers were included in the review, the majority of which represent latest researches in nanosized platforms for the dermal delivery of melatonin including liposomes, ethosomes, niosomes, polymeric nanoparticles, solid lipid nanoparticles and cyclodextrins. Furthermore, relevant papers reporting in vitro and in vivo application studies of these nano-based melatonin platforms were also discussed.
The use of nanoplatforms for the dermal melatonin delivery as antioxidant agent could improve the efficacy of conventional melatonin administration due to the preservation of the drug from premature oxidation and the enhancement of drug permeation through the skin providing greater exposure times.
褪黑素正成为一种有前景的治疗剂，主要因其抗氧化作用。大量证据表明，褪黑素在多种疾病如癌症、炎症和神经退行性疾病中可能有效。其出色的抗氧化能力、药代动力学特性以及对基于新型药物纳米技术系统的不断探索，使得研发基于褪黑素的纳米平台用于生物医学或皮肤美容应用极具吸引力。已对不同的皮肤给药纳米系统进行了研究。
本综述聚焦于纳米载体的制备策略、褪黑素的皮肤应用以及体内外递送进展。同样，也讨论了这种辅助褪黑素递送的未来前景。
在当前综述中，我们使用主要科学数据库对现有文献的相关文章进行了修订。
本综述纳入了113篇论文，其中大部分代表了用于褪黑素皮肤递送的纳米平台的最新研究，包括脂质体、醇质体、非离子脂质体、聚合物纳米颗粒、固体脂质纳米颗粒和环糊精。此外，还讨论了报道这些基于纳米的褪黑素平台体外和体内应用研究的相关论文。
使用纳米平台进行褪黑素的皮肤递送作为抗氧化剂，由于可保护药物免于过早氧化并增强药物透过皮肤能力，延长暴露时间，从而可提高传统褪黑素给药的疗效。
