尿皮质素在心肌缺血再灌注损伤中的心脏保护作用：我们目前的进展如何？
Cardioprotective Utility of Urocortin in Myocardial Ischemia- Reperfusion Injury: Where do We Stand?
作者信息
Basman Craig, Agrawal Pratik, Knight Richard, Saravolatz Louis, McRee Chad, Chen-Scarabelli Carol, Narula Jagat, Scarabelli Tiziano
机构信息
Lenox Hill Hospital, North Shore LIJ Health System, New York, NY. United States.
St. John Hospital and Medical Center, Wayne State University Medical School, Detroit, MI. United States.
出版信息
Curr Mol Pharmacol. 2018;11(1):32-38. doi: 10.2174/1874467210666170223101422.
BACKGROUND
There has been a constant pursuit for development of newer therapies which can contribute to the relatively nascent field of cardioprotection in the setting of myocardial ischemiareperfusion injury. One novel cardioprotective agent among others, that has shown promising results in the limited number of research studies undertaken till now, is Urocortin. Urocortins are peptides belonging to the Corticotropin-Releasing Hormone family.
RESULTS
Acting through a variety of downstream mechanisms, urocortin has been shown to alter cellular metabolism and modulate the mechanism of cell death occurring as a result of ischemia-reperfusion injury. New evidence continues to accumulate in support of urocortin's beneficial role in cytoprotection.
CONCLUSION
We present here an updated review largely focused on the various mechanisms through which urocortin alters cellular metabolism, and discuss the clinical potential of urocortin's cardioprotective ability in myocardial ischemia-reperfusion injury.
背景
在心肌缺血再灌注损伤的背景下，对于能够推动相对新兴的心脏保护领域发展的新型疗法的探索一直在持续。促肾上腺皮质激素释放激素（Urocortin）是迄今开展的有限数量研究中显示出有前景结果的新型心脏保护剂之一。促肾上腺皮质激素释放激素是属于促肾上腺皮质激素释放激素家族的肽类。
结果
通过多种下游机制发挥作用，促肾上腺皮质激素释放激素已被证明可改变细胞代谢，并调节因缺血再灌注损伤而发生的细胞死亡机制。支持促肾上腺皮质激素释放激素在细胞保护中有益作用的新证据不断积累。
结论
我们在此呈现一篇更新的综述，主要聚焦于促肾上腺皮质激素释放激素改变细胞代谢的各种机制，并讨论促肾上腺皮质激素释放激素在心肌缺血再灌注损伤中的心脏保护能力的临床潜力。
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