Hussain Sara J, Thirugnanasambandam Nivethida
Human Cortical Physiology and Neurorehabilitation Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland; and.
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland
J Neurophysiol. 2017 Jun 1;117(6):2085-2087. doi: 10.1152/jn.00060.2017. Epub 2017 Feb 22.
Paired-pulse transcranial magnetic stimulation (TMS) and peripheral stimulation combined with TMS can be used to study cortical interneuronal circuitry. By combining these procedures with concurrent transcranial alternating current stimulation (tACS), Guerra and colleagues recently showed that different cortical interneuronal populations are differentially modulated by the phase and frequency of tACS-imposed oscillations (Guerra A, Pogosyan A, Nowak M, Tan H, Ferreri F, Di Lazzaro V, Brown P. 26: 3977-2990, 2016). This work suggests that different cortical interneuronal populations can be characterized by their phase and frequency dependency. Here we discuss how combining TMS and tACS can reveal the frequency at which cortical interneuronal populations oscillate, the neuronal origins of behaviorally relevant cortical oscillations, and how entraining cortical oscillations could potentially treat brain disorders.
配对脉冲经颅磁刺激（TMS）以及外周刺激与TMS相结合可用于研究皮质中间神经元回路。通过将这些方法与同步经颅交流电刺激（tACS）相结合，格拉（Guerra）及其同事最近表明，不同的皮质中间神经元群体受到tACS施加振荡的相位和频率的不同调制（格拉A，波戈西安A，诺瓦克M，谭H，费雷里F，迪拉扎罗V，布朗P. 26: 3977 - 2990, 2016）。这项工作表明，不同的皮质中间神经元群体可通过其相位和频率依赖性来表征。在这里，我们讨论结合TMS和tACS如何揭示皮质中间神经元群体振荡的频率、行为相关皮质振荡的神经元起源，以及夹带皮质振荡如何可能治疗脑部疾病。
