β经颅交流电刺激期间人类初级运动皮层的相位依赖性与胆碱能抑制消除

Phase Dependency of the Human Primary Motor Cortex and Cholinergic Inhibition Cancelation During Beta tACS.

作者信息

Guerra Andrea, Pogosyan Alek, Nowak Magdalena, Tan Huiling, Ferreri Florinda, Di Lazzaro Vincenzo, Brown Peter

机构信息

Unit of Neurology, Neurophysiology, Neurobiology, Department of Medicine, University Campus Bio-Medico, 00128 Rome, Italy Medical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.

Medical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.

出版信息

Cereb Cortex. 2016 Oct;26(10):3977-90. doi: 10.1093/cercor/bhw245. Epub 2016 Aug 13.

DOI:10.1093/cercor/bhw245

PMID:27522077

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5028010/

Abstract

The human motor cortex has a tendency to resonant activity at about 20 Hz so stimulation should more readily entrain neuronal populations at this frequency. We investigated whether and how different interneuronal circuits contribute to such resonance by using transcranial magnetic stimulation (TMS) during transcranial alternating current stimulation (tACS) at motor (20 Hz) and a nonmotor resonance frequency (7 Hz). We tested different TMS interneuronal protocols and triggered TMS pulses at different tACS phases. The effect of cholinergic short-latency afferent inhibition (SAI) was abolished by 20 Hz tACS, linking cortical beta activity to sensorimotor integration. However, this effect occurred regardless of the tACS phase. In contrast, 20 Hz tACS selectively modulated MEP size according to the phase of tACS during single pulse, GABAAergic short-interval intracortical inhibition (SICI) and glutamatergic intracortical facilitation (ICF). For SICI this phase effect was more marked during 20 Hz stimulation. Phase modulation of SICI also depended on whether or not spontaneous beta activity occurred at ~20 Hz, supporting an interaction effect between tACS and underlying circuit resonances. The present study provides in vivo evidence linking cortical beta activity to sensorimotor integration, and for beta oscillations in motor cortex being promoted by resonance in GABAAergic interneuronal circuits.

摘要

人类运动皮层倾向于在约20赫兹时产生共振活动，因此刺激应更容易在该频率下带动神经元群体。我们通过在运动（20赫兹）和非运动共振频率（7赫兹）的经颅交流电刺激（tACS）期间使用经颅磁刺激（TMS），研究了不同的中间神经元回路是否以及如何促成这种共振。我们测试了不同的TMS中间神经元方案，并在不同的tACS相位触发TMS脉冲。胆碱能短潜伏期传入抑制（SAI）的效应被20赫兹的tACS消除，将皮层β活动与感觉运动整合联系起来。然而，无论tACS相位如何，这种效应都会出现。相比之下，20赫兹的tACS在单脉冲、GABAA能短间隔皮层内抑制（SICI）和谷氨酸能皮层内易化（ICF）期间，根据tACS的相位选择性地调节运动诱发电位（MEP）大小。对于SICI，在20赫兹刺激期间这种相位效应更为明显。SICI的相位调制还取决于是否在约20赫兹出现自发β活动，这支持了tACS与潜在回路共振之间的相互作用效应。本研究提供了体内证据，将皮层β活动与感觉运动整合联系起来，并表明运动皮层中的β振荡是由GABAA能中间神经元回路中的共振促进的。