Ryu Seungho, Chang Yoosoo, Kang Jeonggyu, Kwon Min-Jung, Yun Kyung Eun, Jung Hyun-Suk, Kim Chan-Won, Shin Hocheol, Sung Ki-Chul
Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine.
Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine.
Circ J. 2017 May 25;81(6):823-830. doi: 10.1253/circj.CJ-16-1084. Epub 2017 Feb 22.
The goal of this study was to examine the association of serum γ-glutamyltransferase (GGT) levels with left ventricular (LV) diastolic dysfunction and LV hypertrophy.
A cross-sectional study of 79,459 Korean men and women who underwent an echocardiography as part of a comprehensive health examination between March 2011 and December 2014. The presence of LV diastolic dysfunction and LV hypertrophy was determined using echocardiography. Of the subjects, 5,447 had LV diastolic dysfunction and 2,070 had LV hypertrophy. Both LV diastolic dysfunction and LV hypertrophy were associated with higher levels of serum GGT. Multivariable-adjusted odds ratios (95% confidence interval) for LV diastolic dysfunction comparing serum GGT quartiles 2-4 with quartile 1 were 1.25 (1.08-1.44), 1.65 (1.43-1.91) and 2.23 (1.92-2.58), respectively (P for trend <0.001). Multivariable-adjusted odds ratios (95% CI) for LV hypertrophy comparing serum GGT quartiles 2-4 with quartile 1 were 1.13 (0.94-1.36), 1.14 (0.93-1.40) and 1.33 (1.07-1.65), respectively (P for trend 0.01). These associations of serum GGT levels with LV diastolic dysfunction and LV hypertrophy were modified by age (P for interaction <0.05).
This study demonstrated a positive association between serum GGT levels and LV diastolic dysfunction and LV hypertrophy in a large cohort of middle-aged men and women independent of potential confounders.
本研究的目的是探讨血清γ-谷氨酰转移酶（GGT）水平与左心室（LV）舒张功能障碍及左心室肥厚之间的关联。
对2011年3月至2014年12月期间接受超声心动图检查作为全面健康检查一部分的79459名韩国男性和女性进行了横断面研究。使用超声心动图确定左心室舒张功能障碍和左心室肥厚的存在。在这些受试者中，5447人有左心室舒张功能障碍，2070人有左心室肥厚。左心室舒张功能障碍和左心室肥厚均与血清GGT水平升高有关。将血清GGT四分位数2 - 4与四分位数1相比，左心室舒张功能障碍的多变量调整比值比（95%置信区间）分别为1.25（1.08 - 1.44）、1.65（1.43 - 1.91）和2.23（1.92 - 2.58）（趋势P<0.001）。将血清GGT四分位数2 - 4与四分位数1相比，左心室肥厚的多变量调整比值比（95%CI）分别为1.13（0.94 - 1.36）、1.14（0.93 - 1.40）和1.33（1.07 - 1.65）（趋势P = 0.01）。血清GGT水平与左心室舒张功能障碍和左心室肥厚之间的这些关联因年龄而改变（交互作用P<0.05）。
本研究表明，在一大群中年男性和女性中，血清GGT水平与左心室舒张功能障碍和左心室肥厚之间存在正相关，且不受潜在混杂因素影响。
