Raufi Ali, Alsharedi Mohamed, Khelfa Yousef, Griswold Doreen C, Lebowicz Yehuda
Division of Hematology-Oncology, Department of Medicine, Joan C. Edwards School of Medicine, Marshall University-Edwards Comprehensive Cancer Center, Huntington, WV, USA.
SAGE Open Med Case Rep. 2016 Dec 1;4:2050313X16683624. doi: 10.1177/2050313X16683624. eCollection 2016.
Chronic lymphocytic leukemia, the most common adult leukemia worldwide, is considered an indolent but incurable non-Hodgkin lymphoma. Leukemia cutis is an uncommon manifestation of chronic lymphocytic leukemia. We present a case of an adult patient who presented with skin lesion of bilateral ears, which led to the diagnosis of chronic lymphocytic leukemia. We also reviewed the cases of auricular involvement in chronic lymphocytic leukemia patients reported in the literature. Local treatment is indicated in case of leukemia cutis; however, systemic treatment is recommended when there are systemic signs and symptoms. Better awareness of disease evolution and prompt diagnosis of this leukemia cutis of chronic lymphocytic leukemia will improve the effectiveness and outcome of its management.
慢性淋巴细胞白血病是全球最常见的成人白血病，被认为是一种进展缓慢但无法治愈的非霍奇金淋巴瘤。白血病性皮肤浸润是慢性淋巴细胞白血病的一种罕见表现。我们报告一例成年患者，其双侧耳部出现皮肤病变，最终诊断为慢性淋巴细胞白血病。我们还回顾了文献中报道的慢性淋巴细胞白血病患者耳部受累的病例。对于白血病性皮肤浸润，应采取局部治疗；然而，出现全身症状体征时则建议进行全身治疗。更好地了解疾病进展并及时诊断慢性淋巴细胞白血病的这种白血病性皮肤浸润，将提高其治疗的有效性和预后。
