前美国国家橄榄球联盟球员反复头部撞击暴露与晚年血浆总tau蛋白水平的关系
Repetitive head impact exposure and later-life plasma total tau in former National Football League players.
作者信息
Alosco Michael L, Tripodis Yorghos, Jarnagin Johnny, Baugh Christine M, Martin Brett, Chaisson Christine E, Estochen Nate, Song Linan, Cantu Robert C, Jeromin Andreas, Stern Robert A
机构信息
Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, MA, USA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
出版信息
Alzheimers Dement (Amst). 2016 Dec 10;7:33-40. doi: 10.1016/j.dadm.2016.11.003. eCollection 2017.
INTRODUCTION
Blood protein analysis of total tau (t-tau) may be a practical screening biomarker for chronic traumatic encephalopathy (CTE), a neurodegenerative tauopathy associated with repetitive head impact (RHI) exposure. We examined plasma t-tau in symptomatic former National Football League (NFL) players compared with controls and the relationship between RHI exposure and later-life plasma t-tau.
METHODS
Ninety-six former NFL players (age 40-69) and 25 same-age controls underwent blood draw to determine plasma t-tau levels. The cumulative head impact index (CHII) quantified RHI exposure. Subjects completed measures of clinical function.
RESULTS
A higher CHII predicted greater plasma t-tau in the former NFL players ( = .0137). No group differences in plasma t-tau emerged, but a concentration ≥3.56 pg/mL was 100% specific to former NFL players. Plasma t-tau did not predict clinical function.
DISCUSSION
Greater RHI exposure predicted higher later-life plasma t-tau concentrations, and further study on plasma t-tau as a candidate screening biomarker for CTE is warranted.
引言
总tau蛋白（t-tau）的血液蛋白分析可能是慢性创伤性脑病（CTE）的一种实用筛查生物标志物，CTE是一种与重复性头部撞击（RHI）暴露相关的神经退行性tau蛋白病。我们比较了有症状的前美国国家橄榄球联盟（NFL）球员与对照组的血浆t-tau，并研究了RHI暴露与晚年血浆t-tau之间的关系。
方法
96名前NFL球员（年龄40 - 69岁）和25名同龄对照组接受抽血以测定血浆t-tau水平。累积头部撞击指数（CHII）对RHI暴露进行量化。受试者完成临床功能测量。
结果
较高的CHII预测前NFL球员的血浆t-tau水平更高（P = 0.0137）。血浆t-tau未出现组间差异，但浓度≥3.56 pg/mL对前NFL球员具有100%的特异性。血浆t-tau不能预测临床功能。
讨论
更高的RHI暴露预测晚年血浆t-tau浓度更高，因此有必要进一步研究将血浆t-tau作为CTE的候选筛查生物标志物。
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