Alosco Michael L, Morrison Madeline, Au Rhoda, Steinberg Eric G, Mwicigi Jane, Ly Monica, Altaras Caroline, Lenio Steve, Abdennadher Myriam, O'Connor Maureen K, Tripodis Yorghos, Palmisano Joseph, Dixon Diane, Martin Brett, Schneider Greta, Groh Jenna R, Ellison Andrew, Sheppard Dean, Farris Chad W, Nowinski Christopher, Cantu Robert C, Turk Katherine W, Farrer Lindsay, Jun Gyungah, Goldstein Lee E, Qiu Wei Qiao, Stein Thor D, Budson Andrew E, McKee Ann C, Mez Jesse
Boston University Alzheimer's Disease Research Center and BU CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Department of Neurology, Boston Medical Center, Boston, Massachusetts, USA.
Alzheimers Dement. 2025 Sep;21(9):e70654. doi: 10.1002/alz.70654.
We describe the rationale, methodology, and design of the Boston University Alzheimer's Disease Research Center (BU ADRC) Clinical Core (CC). The CC characterizes a longitudinal cohort of participants with/without brain trauma to characterize the clinical presentation, biomarker profiles, and risk factors of post-traumatic Alzheimer's disease (AD) and AD-related dementias (ADRD), including chronic traumatic encephalopathy (CTE). Participants complete assessments of traumatic brain injury (TBI) and repetitive head impacts (RHIs); annual Uniform Data Set (UDS) and supplementary evaluations; digital phenotyping; annual blood draw; magnetic resonance imaging (MRI) and lumbar puncture every 3 years; electroencephalogram (EEG); and amyloid and/or tau positron emission tomography (PET) on a subset. As of 3/2025, the CC consists of 467 participants (mean age: 65.6, 50.1% female), including 163 RHI and 302 TBI who completed a UDS 3.0 baseline visit. Common sources of RHI included football (n = 95), soccer (n = 26), ice hockey (n = 17), and military service (n = 46). Most TBIs were mild (97.7%). Eighty-nine percent agreed to brain donation. The BU ADRC CC will facilitate research, education, and training on post-traumatic AD/ADRD. HIGHLIGHTS: The Boston University Alzheimer's Disease Research Center (ADRC) Clinical Core facilitates unique research, education, and training on Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD) with a focus on post-traumatic AD/ADRD, including chronic traumatic encephalopathy (CTE). We summarize the rationale, mission, study design, and recent updates for the Clinical Core. As of March 2025, the Clinical Core includes a longitudinal cohort of 467 participants enriched for repetitive head impacts (∼1/3) and traumatic brain injury (∼1/3) exposure who span the cognitive continuum, with most having available fluid and neuroimaging biomarker data and agreeing to brain donation (89%).
我们描述了波士顿大学阿尔茨海默病研究中心（BU ADRC）临床核心（CC）的基本原理、方法和设计。该临床核心对有/无脑外伤的参与者进行纵向队列研究，以描述创伤后阿尔茨海默病（AD）和AD相关痴呆（ADRD），包括慢性创伤性脑病（CTE）的临床表现、生物标志物谱和危险因素。参与者完成创伤性脑损伤（TBI）和重复性头部撞击（RHI）评估；年度统一数据集（UDS）和补充评估；数字表型分析；年度血液采集；每3年进行一次磁共振成像（MRI）和腰椎穿刺；脑电图（EEG）；以及对一部分参与者进行淀粉样蛋白和/或tau正电子发射断层扫描（PET）。截至2025年3月，临床核心包括467名参与者（平均年龄：65.6岁，50.1%为女性），其中163名有重复性头部撞击经历者和302名创伤性脑损伤患者完成了UDS 3.0基线访视。重复性头部撞击的常见来源包括足球（n = 95）、足球（n = 26）、冰球（n = 17）和军事服役（n = 46）。大多数创伤性脑损伤为轻度（97.7%）。89%的参与者同意进行脑捐赠。BU ADRC临床核心将促进关于创伤后AD/ADRD的研究、教育和培训。要点：波士顿大学阿尔茨海默病研究中心（ADRC）临床核心促进了关于阿尔茨海默病和阿尔茨海默病相关痴呆（AD/ADRD）的独特研究、教育和培训，重点是创伤后AD/ADRD，包括慢性创伤性脑病（CTE）。我们总结了临床核心的基本原理、使命、研究设计和近期更新情况。截至2025年3月，临床核心包括一个由46个参与者组成的纵向队列，这些参与者因重复性头部撞击（约1/3）和创伤性脑损伤（约1/3）暴露而富集，涵盖认知连续体，大多数人有可用的体液和神经影像学生物标志物数据，并同意进行脑捐赠（89%）。
