Marinho António, Taveira Mariana, Vasconcelos Carlos
UMIB, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), U.Porto, 4099-001, Porto, Portugal.
Unidade Imunologia Clínica, Centro Hospitalar do Porto, Hospital Santo António, Porto, Portugal.
Immunol Res. 2017 Apr;65(2):495-511. doi: 10.1007/s12026-017-8903-5.
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with multiorgan inflammation, linked to the loss of immune tolerance to self-antigens and the production of a diversity of autoantibodies. The phenotype and progression of SLE have been linked to a combination of environmental, genetic, and hormonal factors. One such environmental factor is vitamin D, a vital hormone with well-established effects on mineral metabolism, skeletal health, and effects on cardiovascular system. The purpose of this article is to make the analysis of evidence and literature review of the pleomorphic effects of Vitamin D in SLE. The article is structured in topics of interest based in the authors' opinion and summarizes the evidence of studies and trials of vitamin D in SLE.
系统性红斑狼疮（SLE）是一种伴有多器官炎症的系统性自身免疫性疾病，与自身抗原免疫耐受的丧失及多种自身抗体的产生有关。SLE的表型和进展与环境、遗传和激素因素的综合作用有关。维生素D就是这样一种环境因素，它是一种重要的激素，对矿物质代谢、骨骼健康以及心血管系统均有明确的影响。本文旨在对维生素D在SLE中的多形性作用进行证据分析和文献综述。本文根据作者的观点，围绕感兴趣的主题进行架构，总结了维生素D在SLE中的研究和试验证据。
