Key Laboratory of Biomedical Polymers of Ministry of Education & College of Chemistry and Molecular Sciences, Wuhan University , Wuhan, Hubei 430072, China.
Department of Chemistry, South University of Science and Technology of China , Shenzhen, Guangdong 518055, P. R. China.
Org Lett. 2017 Mar 3;19(5):1024-1027. doi: 10.1021/acs.orglett.6b03845. Epub 2017 Feb 23.
Rh/(S)-(+)-DTBM-Segphos complex catalyzed asymmetric hydrogenation of α-substituted vinyl sulfones has been achieved, furnishing the desired products in high yields and excellent enantioselectivities (>90% yield, up to 99% ee). This method provided an efficient approach to α-substituted chiral sulfones under mild conditions and has potential applications in organic synthesis.
Rh/(S)-(+)-DTBM-Segphos 配合物催化的 α-取代乙烯基砜的不对称氢化已经实现，以高收率和优异的对映选择性（>90%产率，高达 99%ee）得到所需产物。该方法在温和条件下为 α-取代手性砜提供了一种有效的合成途径，在有机合成中有潜在的应用。
