Warren Christopher M, van den Brink Ruud L, Nieuwenhuis Sander, Bosch Jos A
Institute of Psychology, Leiden University, Leiden 2333 AK, Netherlands; Leiden Institute for Brain and Cognition, Leiden University, Leiden 2300 RC, Netherlands.
Institute of Psychology, Leiden University, Leiden 2333 AK, Netherlands; Leiden Institute for Brain and Cognition, Leiden University, Leiden 2300 RC, Netherlands.
Psychoneuroendocrinology. 2017 Apr;78:233-236. doi: 10.1016/j.psyneuen.2017.01.029. Epub 2017 Jan 31.
It has been suggested that central norepinephrine (NE) activity may be inferred from increases in salivary alpha-amylase (SAA), but data in favor of this proposition are limited. We administered 40mg of atomoxetine, a selective NE transporter blocker that increases central NE levels, to 24 healthy adult participants in a double-blind, placebo-controlled cross-over design. Atomoxetine administration significantly increased SAA secretion and concentrations at 75-180min after treatment (more than doubling baseline levels). Consistent with evidence that elevation in central NE is a co-determinant of hypothalamic-pituitary-adrenal axis activity, salivary cortisol also approximately doubled at the same time points. Moreover, changes in salivary cortisol positively correlated with SAA (0.44<rho<0.56), bolstering the position that the origin of the changes in SAA reflect central NE. This work points toward the potential value of SAA as an inexpensive and non-invasive procedure to obtain information about activation of the central NE system.
有人提出，可通过唾液α-淀粉酶（SAA）的增加来推断中枢去甲肾上腺素（NE）的活性，但支持这一观点的数据有限。我们采用双盲、安慰剂对照的交叉设计，给24名健康成年参与者服用40毫克托莫西汀，这是一种可提高中枢NE水平的选择性NE转运体阻滞剂。服用托莫西汀后，在治疗后75 - 180分钟时，SAA的分泌和浓度显著增加（比基线水平增加了一倍多）。与中枢NE升高是下丘脑 - 垂体 - 肾上腺轴活动的共同决定因素的证据一致，唾液皮质醇在相同时间点也大约增加了一倍。此外，唾液皮质醇的变化与SAA呈正相关（0.44 < ρ < 0.56），这支持了SAA变化的来源反映中枢NE的观点。这项研究表明，SAA作为一种获取中枢NE系统激活信息的廉价且非侵入性方法具有潜在价值。
