University of Southern California, Los Angeles, CA 90089, USA.
University of California, Irvine, Irvine, CA 92697, USA.
Neurobiol Aging. 2023 Dec;132:85-99. doi: 10.1016/j.neurobiolaging.2023.08.010. Epub 2023 Sep 1.
Using data from a clinical trial, we tested the hypothesis that daily sessions modulating heart rate oscillations affect older adults' volume of a region-of-interest (ROI) comprised of adjacent hippocampal subregions with relatively strong locus coeruleus (LC) noradrenergic input. Younger and older adults were randomly assigned to one of two daily biofeedback practices for 5 weeks: (1) engage in slow-paced breathing to increase the amplitude of oscillations in heart rate at their breathing frequency (Osc+); (2) engage in self-selected strategies to decrease heart rate oscillations (Osc-). The interventions did not significantly affect younger adults' hippocampal volume. Among older adults, the two conditions affected volume in the LC-targeted hippocampal ROI differentially as reflected in a significant condition × time-point interaction on ROI volume. These condition differences were driven by opposing changes in the two conditions (increased volume in Osc+ and decreased volume in Osc-) and were mediated by the degree of heart rate oscillation during training sessions.
利用临床试验数据，我们检验了这样一个假设，即每天调节心率振荡的训练可以影响老年人包含相邻海马亚区的感兴趣区域（ROI）的体积，这些亚区接受相对较强的蓝斑核（LC）去甲肾上腺素能输入。年轻和老年参与者被随机分配到两种每日生物反馈练习中的一种，持续 5 周：（1）进行慢节奏呼吸以增加心率在呼吸频率时的振荡幅度（Osc+）；（2）采用自我选择的策略来降低心率振荡（Osc-）。这些干预措施并没有显著影响年轻人的海马体体积。在老年人中，两种情况对 LC 靶向海马 ROI 的体积有不同的影响，这反映在 ROI 体积上存在显著的条件-时间点交互作用。这些条件差异是由两种情况的相反变化（Osc+中体积增加，Osc-中体积减少）驱动的，而这种变化则受到训练期间心率振荡程度的影响。
