性染色体进化中的趋同与分歧。

Convergence and divergence in sex-chromosome evolution.

机构信息

Institute of Ecology and Evolution, University of Bern, Bern, Switzerland.

出版信息

Nat Genet. 2017 Feb 24;49(3):321-322. doi: 10.1038/ng.3797.

Abstract

A sequence assembly of the chicken W chromosome enables reconstruction of the gene content of the W chromosome across 14 bird species and shows striking similarities in the maintenance of broadly expressed and dosage-sensitive genes on highly degenerate sex chromosomes in both birds and mammals. However, the chicken W chromosome is not enriched for genes with expression in female-specific tissues, providing an intriguing contrast to the acquisition and amplification of genes with testis-specific expression on mammalian Y chromosomes and suggesting that the inheritance of chromosomes solely through females or males can lead to different evolutionary outcomes.

摘要

鸡 W 染色体的序列组装使我们能够重建 14 种鸟类的 W 染色体的基因内容，并表明在鸟类和哺乳动物中高度退化的性染色体上维持广泛表达和剂量敏感基因方面存在惊人的相似性。然而，鸡 W 染色体并不富集在雌性组织特异性表达的基因，这与哺乳动物 Y 染色体上获得和扩增睾丸特异性表达的基因形成了有趣的对比，并表明仅通过雌性或雄性遗传染色体可能会导致不同的进化结果。