Boissier Romain, Campagna Jennifer, Branger Nicolas, Karsenty Gilles, Lechevallier Eric
Aix-Marseille University, Marseille, France; Department of Urology and Renal Transplantation, APHM, Conception University Hospital, Marseille, France.
Aix-Marseille University, Marseille, France; Department of Urology and Renal Transplantation, APHM, Conception University Hospital, Marseille, France.
Urol Oncol. 2017 Apr;35(4):135-141. doi: 10.1016/j.urolonc.2017.01.016. Epub 2017 Feb 21.
The neutrophil-lymphocyte ratio (NLR) is a biological marker of inflammation with a significant prognostic value in the field of oncology.
In this review, we discuss the prognostic value of the NLR in renal cell carcinoma (RCC).
We conducted a literature review of the PubMed database in August 2016. Initial research identified 31 publications. Following full-text screening, 15 studies were finally included: 7 studies concerning metastatic or locally advanced renal cancer, 6 studies dealing with localized renal cancer, 2 articles evaluating the NLR in renal cancer whatever the status of the disease (metastatic or localized).
For localized RCC, an NLR o 3 was predictive of a reduced risk of recurrence (hazard ratio ¼ 1.63 [1.15, 2.29]). The prognostic value of the NLR was stronger for metastatic or locally advanced RCC. An NLR o 3 predicted increased overall survival (hazard ratio ¼ 1.55 [1.36, 1.76]), progression-free survivals (hazard ratio ¼ 3.19 [2.23, 4.57]), and a response to systemic treatment.
In current practice, the NLR is a simple and inexpensive prognostic factor with potential improvement in the prognostic performance of nomograms used in renal oncology.
中性粒细胞与淋巴细胞比值（NLR）是一种炎症生物标志物，在肿瘤学领域具有重要的预后价值。
在本综述中，我们讨论NLR在肾细胞癌（RCC）中的预后价值。
我们于2016年8月对PubMed数据库进行了文献综述。初步检索确定了31篇出版物。经过全文筛选，最终纳入15项研究：7项关于转移性或局部晚期肾癌的研究，6项关于局限性肾癌的研究，2篇评估无论疾病状态（转移性或局限性）的肾癌患者的NLR的文章。
对于局限性RCC，NLR＞3预示复发风险降低（风险比=1.63[1.15,2.29]）。NLR对转移性或局部晚期RCC的预后价值更强。NLR＞3预示总生存期延长（风险比=1.55[1.36,1.76]）、无进展生存期延长（风险比=3.19[2.23,4.57]）以及对全身治疗有反应。
在当前实践中，NLR是一种简单且廉价的预后因素，可能会改善肾肿瘤学中使用的列线图的预后性能。
