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Folate-mediated chemotherapy and diagnostics: An updated review and outlook.

作者信息

Xu Leyuan, Bai Qianming, Zhang Xin, Yang Hu

机构信息

Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA 23284, United States; Department of Internal Medicine, Yale University, New Haven, CT 06520, United States.

Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.

出版信息

J Control Release. 2017 Apr 28;252:73-82. doi: 10.1016/j.jconrel.2017.02.023. Epub 2017 Feb 22.

DOI:10.1016/j.jconrel.2017.02.023
PMID:28235591
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5479736/
Abstract

Folate receptor (FR) is highly expressed in many types of human cancers, and it has been actively studied for developing targeted chemotherapy and diagnostic agents. Tremendous efforts have been made in developing FR-targeted nanomedicines and nanoprobes and translating them into clinical applications. This article provides a concise review on the latest development of folate-mediated nanomedicines and nanoprobes for chemotherapy and diagnostics with an emphasis on in vivo applications. The cellular uptake mechanisms, pharmacokinetics (PK), administration routes and major challenges in FR-targeted nanoparticles are discussed.

摘要

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本文引用的文献

[1]
Folic acid-decorated polyamidoamine dendrimer mediates selective uptake and high expression of genes in head and neck cancer cells.

Nanomedicine (Lond). 2016-11

[2]
Injectable hydrogel-based drug delivery systems for local cancer therapy.

Drug Discov Today. 2016-7-14

[3]
Photosensitizer enhanced disassembly of amphiphilic micelle for ROS-response targeted tumor therapy in vivo.

Biomaterials. 2016-7-5

[4]
Liquid crystalline nanoparticles encapsulating cisplatin and docetaxel combination for targeted therapy of breast cancer.

Biomater Sci. 2016-8-16

[5]
Utilizing G2/M retention effect to enhance tumor accumulation of active targeting nanoparticles.

Sci Rep. 2016-6-8

[6]
Magnetically and pH dual responsive dendrosomes for tumor accumulation enhanced folate-targeted hybrid drug delivery.

J Control Release. 2016-4-14

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A Multi-Functional Tumor Theranostic Nanoplatform for MRI Guided Photothermal-Chemotherapy.

Pharm Res. 2016-6

[8]
In situ crosslinked smart polypeptide nanoparticles for multistage responsive tumor-targeted drug delivery.

Nanoscale. 2016-3-21

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A magnetic vehicle realized tumor cell-targeted radiotherapy using low-dose radiation.

J Control Release. 2016-3-28

[10]
Targeted modulation of cell differentiation in distinct regions of the gastrointestinal tract via oral administration of differently PEG-PEI functionalized mesoporous silica nanoparticles.

Int J Nanomedicine. 2016-1-18

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