Sun Chao, Li Shuqiang, Ding Jianxun
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, P. R. China.
Department of Orthopedic Surgery, Orthopedic Center, The First Hospital of Jilin University, Jilin University, Changchun, P. R. China.
Nanomedicine (Lond). 2025 Feb;20(4):417-425. doi: 10.1080/17435889.2025.2451018. Epub 2025 Jan 12.
Recent advancements in tumor therapy have underscored the potential of biomaterials-mediated biomineralization for tumor blockade. By precisely regulating biomineralization and constructing nanomineralized structures at the cellular level, this therapy achieves multi-dimensional targeted inhibition of tumors. Mineralized precursor molecules are engineered to selectively recognize and bind to proteins on the tumor cell membrane, obstructing signal transduction. Biomineralized materials directly target the tumor cell membrane, disrupting its biological functions and inducing cell apoptosis. Additionally, these materials infiltrate the mitochondria of tumor cells, disrupting energy metabolism through mineralization and significantly impairing tumor viability. This biomaterials-mediated approach enhances treatment precision and efficacy while mitigating side effects, offering a unique approach to tumor therapy.
肿瘤治疗的最新进展凸显了生物材料介导的生物矿化在肿瘤阻断方面的潜力。通过在细胞水平精确调控生物矿化并构建纳米矿化结构，这种疗法实现了对肿瘤的多维度靶向抑制。矿化前体分子经过设计，可选择性识别并结合肿瘤细胞膜上的蛋白质，阻碍信号转导。生物矿化材料直接靶向肿瘤细胞膜，破坏其生物学功能并诱导细胞凋亡。此外，这些材料会渗透到肿瘤细胞的线粒体中，通过矿化破坏能量代谢，显著损害肿瘤的生存能力。这种生物材料介导的方法提高了治疗的精准度和疗效，同时减轻了副作用，为肿瘤治疗提供了一种独特的方法。
