埃洛石纳米管在药用辅料中的应用。
Application of halloysite clay nanotubes as a pharmaceutical excipient.
机构信息
Institute for Micromanufacturing, Louisiana Tech University, Ruston, LA 71272, USA.
School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, USA.
出版信息
Int J Pharm. 2017 Apr 15;521(1-2):267-273. doi: 10.1016/j.ijpharm.2017.02.055. Epub 2017 Feb 21.
Halloysite nanotubes, a biocompatible nanomaterial of 50-60nm diameter and ca. 15nm lumen, can be used for loading, storage and sustained release of drugs either in its pristine form or with additional polymer complexation for extended release time. This study reports the development composite tablets based on 50wt.% of the drug loaded halloysite mixed with 45wt.% of microcrystalline cellulose. Powder flow and compressibility properties of halloysite (angle of repose, Carr's index, Hausner ratio, Brittle Fracture Index, tensile strength) indicate that halloysite is an excellent tablet excipient. Halloysite tubes can also be filled with nifedipine with ca. 6wt.% loading efficiency and sustained release from the nanotubes. Tablets prepared with drug loaded halloysite allowed for almost zero order nifedipine release for up to 20h. Nifedipine trapped in the nanotubes also protect the drug against light and significantly increased the photostability of the drug. All of these demonstrate that halloysite has the potential to be an excellent pharmaceutical excipient that is also an inexpensive, natural and abundantly available material.
埃洛石纳米管,一种生物相容性的纳米材料,直径为 50-60nm,内腔约 15nm,可用于负载、储存和药物的持续释放,无论是在其原始形式还是与额外的聚合物复合以延长释放时间。本研究报告了基于负载药物的埃洛石(50wt.%)与 45wt.%微晶纤维素混合的复合片剂的开发。埃洛石(堆积角、卡尔指数、哈纳斯比、脆性断裂指数、拉伸强度)的粉末流动和可压缩性表明埃洛石是一种极好的片剂赋形剂。埃洛石管也可以填充硝苯地平,载药量约为 6wt.%,并从纳米管中持续释放。用负载药物的埃洛石制备的片剂允许硝苯地平以近零级的速度释放长达 20 小时。被困在纳米管中的硝苯地平也能保护药物免受光照,并显著提高药物的光稳定性。所有这些都表明埃洛石具有成为一种优秀的药物赋形剂的潜力,同时也是一种廉价、天然和丰富的材料。