da Rocha Monsuêto C, Galdino Thais, Trigueiro Pollyana, Honorio Luzia M C, de Melo Barbosa Raquel, Carrasco Santiago M, Silva-Filho Edson C, Osajima Josy A, Viseras César
Interdisciplinary Laboratory for Advanced Materials, LIMAV, UFPI, Teresina 64049-550, PI, Brazil.
Materials Science and Engineering Postgraduate Program, PGCM/CCSST, UFMA, Imperatriz 65900-410, MA, Brazil.
Pharmaceutics. 2022 Apr 5;14(4):796. doi: 10.3390/pharmaceutics14040796.
Clay minerals are often used due to their high adsorption capacity, which has sparked interest in their biological applications to stabilize drugs and pharmaceutical products. This research aims to summarize information about the stability of drugs, cosmetics, dermocosmetics, and pharmaceutical compounds incorporated in the structure of different clay minerals. The databases used to search the articles were Web of Science, Scopus, PubMed, and Science Direct. Photostabilization of these compounds is reviewed and its importance demonstrated. For biological applications, the increase in solubility and bioavailability of clay minerals has proven useful for them as drug carriers. While their natural abundance, low toxicity, and accessible cost have contributed to classical applications of clay minerals, a wide range of interesting new applications may be facilitated, mainly through incorporating different organic molecules. The search for new functional materials is promising to challenge research on clay minerals in biological or biotechnological approaches.
粘土矿物因其高吸附能力而经常被使用，这引发了人们对其在生物应用中稳定药物和药品的兴趣。本研究旨在总结有关不同粘土矿物结构中所含药物、化妆品、皮肤化妆品和药物化合物稳定性的信息。用于搜索文章的数据库有科学网、Scopus、PubMed和科学Direct。本文综述了这些化合物的光稳定作用并证明了其重要性。对于生物应用，粘土矿物溶解度和生物利用度的提高已证明对其作为药物载体很有用。虽然粘土矿物的天然丰度、低毒性和可承受的成本促成了其传统应用，但主要通过引入不同的有机分子，可能会促进一系列有趣的新应用。寻找新型功能材料有望挑战粘土矿物在生物或生物技术方法方面的研究。
