[一名58岁男性自体干细胞移植后丙型肝炎病毒感染的自发缓解]
[Spontaneous remission of HCV infection after autologous stem cell transplantation in a 58-year-old man].
作者信息
Reinhardt L, Eiffert H, Wulf G, Ströbel P, Bremer S C B, Amanzada A, Ellenrieder V, Neesse A
机构信息
Klinik für Gastroenterologie und gastrointestinale Onkologie, Universitätsmedizin Göttingen, Göttingen, Deutschland.
Leberzentrum Göttingen, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Deutschland.
出版信息
Internist (Berl). 2017 Jun;58(6):621-625. doi: 10.1007/s00108-017-0206-3.
We report about a 58-year-old man with a chronic and treatment-naive hepatitis C virus (HCV) infection of genotype 1b, who had undergone autologous stem cell transplantation twice due to multiple myeloma. Subsequently, a high-level viremic reactivation of an occult hepatitis B virus (HBV) infection and also a reverse seroconversion was observed. Furthermore, a sustained spontaneous remission of HCV infection was seen. Antiviral therapy of HBV infection was initiated with tenofovir. Seven months after therapy initiation, the patient acquired an "anti-HBc-only" status. Antiviral therapy with tenofovir is still continued. The patient is in a good clinical condition.
我们报告了一名58岁男性，患有基因型1b的慢性丙型肝炎病毒（HCV）感染且未经治疗，因多发性骨髓瘤接受了两次自体干细胞移植。随后，观察到隐匿性乙型肝炎病毒（HBV）感染的高水平病毒血症再激活以及血清学反向转换。此外，还发现HCV感染持续自发缓解。开始使用替诺福韦对HBV感染进行抗病毒治疗。治疗开始七个月后，患者获得了“仅抗-HBc”状态。替诺福韦抗病毒治疗仍在继续。患者临床状况良好。
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