Shi Ling-Min, Chen Rui-Jie, Zhang Hui, Jiang Chun-Ming, Gong Jian
Department of Pediatric Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, People's Republic of China.
Department of Pharmacy, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, People's Republic of China.
Childs Nerv Syst. 2017 May;33(5):805-811. doi: 10.1007/s00381-017-3359-4. Epub 2017 Feb 24.
In the present study, the levels of neuron-specific enolase (NSE), interleukin-1β (IL-1β), and erythropoietin (EPO) in cerebrospinal fluid (CSF) in children with idiopathic epilepsy were measured to illuminate the relationships between these markers with idiopathic epilepsy.
Eighty-five children from 6 months to 12.5 years of age with single, previously undiagnosed, and untreated idiopathic epilepsy were participated in this study. The concentrations of CSF NSE, 1L-1β, and EPO were measured by specific ELISA methods.
The mean concentrations of CSF NSE, IL-1β, and EPO in the epileptic groups showed a significant increase (P < 0.01) compared with those in the control groups. Besides, the mutual correlations of NSE, 1L-1β, and EPO were also analyzed. Results showed that there were positive correlations between the levels of IL-1β, NSE, and EPO.
The changes of NSE, 1L-1β, and EPO level in CSF may be beneficial for the pathophysiology study of epileptic seizures and the identification and diagnosis of a seizure clinically.
在本研究中，测量特发性癫痫患儿脑脊液（CSF）中神经元特异性烯醇化酶（NSE）、白细胞介素-1β（IL-1β）和促红细胞生成素（EPO）的水平，以阐明这些标志物与特发性癫痫之间的关系。
85名年龄在6个月至12.5岁之间、患有单一的、先前未诊断且未治疗的特发性癫痫的儿童参与了本研究。通过特异性酶联免疫吸附测定（ELISA）方法测量脑脊液中NSE、IL-1β和EPO的浓度。
与对照组相比，癫痫组脑脊液中NSE、IL-1β和EPO的平均浓度显著升高（P<0.01）。此外，还分析了NSE、IL-1β和EPO之间的相互相关性。结果显示，IL-1β、NSE和EPO水平之间存在正相关。
脑脊液中NSE、IL-1β和EPO水平的变化可能有助于癫痫发作的病理生理学研究以及临床上癫痫发作的识别和诊断。
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