Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, People's Republic of China.
Jiangsu Co-Innovation Center of Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu, People's Republic of China.
Int J Nanomedicine. 2023 Jun 14;18:3177-3210. doi: 10.2147/IJN.S407029. eCollection 2023.
Exosomes are nanovesicles with a wide range of chemical compositions used in many different applications. Mesenchymal stem cell-derived exosomes (MSCs-EXOs) are spherical vesicles that have been shown to mediate tissue regeneration in a variety of diseases, including neurological, autoimmune and inflammatory, cancer, ischemic heart disease, lung injury, and liver fibrosis. They can modulate the immune response by interacting with immune effector cells due to the presence of anti-inflammatory compounds and are involved in intercellular communication through various types of cargo. MSCs-EXOs exhibit cytokine storm-mitigating properties in response to COVID-19. This review discussed the potential function of MSCs-EXOs in a variety of diseases including neurological, notably epileptic encephalopathy and Parkinson's disease, cancer, angiogenesis, autoimmune and inflammatory diseases. We provided an overview of exosome biogenesis and factors that regulate exosome biogenesis. Additionally, we highlight the functions and potential use of MSCs-EXOs in the treatment of the inflammatory disease COVID-19. Finally, we covered a strategies and challenges of MSCs-EXOs. Finally, we discuss conclusion and future perspectives of MSCs-EXOs.
外泌体是具有广泛化学成分的纳米囊泡，可用于许多不同的应用。间充质干细胞来源的外泌体（MSCs-EXOs）是球形囊泡，已被证明可在多种疾病中介导组织再生，包括神经、自身免疫和炎症、癌症、缺血性心脏病、肺损伤和肝纤维化。由于存在抗炎化合物，它们可以通过与免疫效应细胞相互作用来调节免疫反应，并通过各种类型的货物参与细胞间通讯。MSCs-EXOs 在应对 COVID-19 时表现出减轻细胞因子风暴的特性。本综述讨论了 MSCs-EXOs 在多种疾病中的潜在功能，包括神经疾病，特别是癫痫脑病和帕金森病、癌症、血管生成、自身免疫和炎症性疾病。我们概述了外泌体的生物发生以及调节外泌体生物发生的因素。此外，我们强调了 MSCs-EXOs 在治疗 COVID-19 炎症性疾病中的作用和潜在用途。最后，我们讨论了 MSCs-EXOs 的策略和挑战。最后，我们讨论了 MSCs-EXOs 的结论和未来展望。
