Macedo Sofia, Torres Tiago, Santos Miguel M
CIMAR/CIIMAR - Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Group of Endocrine disruptors and Emerging contaminants, Av. General Norton de Matos s/n, 4450-208, Porto, Portugal.
FCUP-Department of Biology, Faculty of Sciences, University of Porto, Rua do Campo Alegre, Porto, 4169-007, Portugal.
Ecotoxicology. 2017 May;26(4):482-489. doi: 10.1007/s10646-017-1778-3. Epub 2017 Feb 24.
The presence of emerging pollutants in the environment is of major concern not only because of the potential negative impact in human health, but also due to the potential toxicity to non-target organisms. Within the personal and care products (PCPs), the disinfectant Triclosan (TCS) is one of the most concerning compounds. Once in the wastewater treatment plants (WWTPs), a small part of TCS can be biotransformed into a more persistent by-product: methyl-triclosan (M-TCS). Although several studies have focused on the occurrence of this compound in the water systems, the information on its toxicity to aquatic organisms is very limited. Here, we used embryo bioassays with two aquatic model animals to improve risk assessment of M-TCS; zebrafish (Danio rerio) embryo bioassays run up to 144 h post fertilization (hpf) and sea urchin (Paracentrotus lividus) up to 48 hpf, following established protocols. M-TCS and TCS exhibited similar toxicity to zebrafish with a NOEC of 160 µg/L. In contrast, M-TCS induced a delay in the development of the sea urchin larvae at all tested concentrations (1-1000 µg/L), whereas NOEC of TCS for P. lividus embryos was 40 µg/L. Overall, given the reported effects of M-TCS in the close range of environmentally relevant concentrations, and considering the low degradation rate and tendency to bioaccumulation (logKow: 5.2), further studies are warrant to better characterize the risk of this TCS metabolite to aquatic organisms.
环境中新兴污染物的存在备受关注，这不仅是因为其可能对人类健康产生负面影响，还因其可能对非目标生物具有毒性。在个人护理产品（PCP）中，消毒剂三氯生（TCS）是最令人担忧的化合物之一。一旦进入污水处理厂（WWTP），一小部分TCS可生物转化为一种更持久的副产物：甲基三氯生（M-TCS）。尽管已有多项研究聚焦于该化合物在水系统中的出现情况，但其对水生生物毒性的信息却非常有限。在此，我们使用两种水生模式动物进行胚胎生物测定，以改进对M-TCS的风险评估；按照既定方案，斑马鱼（Danio rerio）胚胎生物测定持续至受精后144小时（hpf），海胆（Paracentrotus lividus）胚胎生物测定持续至48 hpf。M-TCS和TCS对斑马鱼表现出相似的毒性，无可见效应浓度（NOEC）为160μg/L。相比之下，M-TCS在所有测试浓度（1 - 1000μg/L）下均导致海胆幼虫发育延迟，而TCS对紫海胆胚胎的NOEC为40μg/L。总体而言，鉴于已报道的M-TCS在与环境相关浓度的相近范围内的影响，并考虑到其低降解率和生物累积趋势（logKow：5.2），有必要开展进一步研究，以更好地描述这种TCS代谢物对水生生物的风险。
