Noale Marianna, Maggi Stefania, Artibani Walter, Bassi Pier Francesco, Bertoni Filippo, Bracarda Sergio, Conti Giario Natale, Corvò Renzo, Gacci Mauro, Graziotti Pierpaolo, Magrini Stefano Maria, Maurizi Enrici Riccardo, Mirone Vincenzo, Montironi Rodolfo, Muto Giovanni, Pecoraro Stefano, Porreca Angelo, Ricardi Umberto, Tubaro Andrea, Zagonel Vittorina, Zattoni Filiberto, Crepaldi Gaetano
CNR, Aging Branch, Neuroscience Institute, Via Giustiniani 2, 35128, Padova, Italy.
Azienda Ospedaliera Universitaria integrata di Verona, Verona, Italy.
Aging Clin Exp Res. 2017 Apr;29(2):165-172. doi: 10.1007/s40520-017-0735-6. Epub 2017 Feb 24.
The Pros-IT CNR project aims to monitor a sample of Italian males ≥18 years of age who have been diagnosed in the participating centers with incident prostate cancer, by analyzing their clinical features, treatment protocols and outcome results in relation to quality of life.
Pros-IT CNR is an observational, prospective, multicenter study. The National Research Council (CNR), Neuroscience Institute, Aging Branch (Padua) is the promoting center. Ninety-seven Italian centers located throughout Italy were involved. The field study began in September 1, 2014. Subjects eligible were diagnosed with biopsy-verified prostate cancer, naïve. A sample size of 1500 patients was contemplated. A baseline assessment including anamnestic data, clinical history, risk factors, the initial diagnosis, cancer staging information and quality of life (Italian UCLA Prostate Cancer Index; SF-12 Scale) was completed. Six months after the initial diagnosis, a second assessment evaluating the patient's health status, the treatment carried out, and the quality of life will be made. A third assessment, evaluating the treatment follow-up and the quality of life, will be made 12 months after the initial diagnosis. The 4th, 5th, 6th and 7th assessments, similar to the third, will be completed 24, 36, 48 and 60 months after the initial diagnosis, respectively, and will include also a Food Frequency Questionnaire and the Physical Activity Scale for the Elderly.
The study will provide information on patients' quality of life and its variations over time in relation to the treatments received for the prostate cancer.
Pros-IT CNR项目旨在通过分析意大利18岁及以上被参与中心诊断为新发前列腺癌的男性样本的临床特征、治疗方案及与生活质量相关的结果，来对其进行监测。
Pros-IT CNR是一项观察性、前瞻性、多中心研究。国家研究委员会（CNR）神经科学研究所衰老分部（帕多瓦）是发起中心。意大利各地的97个中心参与其中。实地研究于2014年9月1日开始。符合条件的受试者为经活检证实的初发前列腺癌患者。计划样本量为1500例患者。完成了包括记忆数据、临床病史、危险因素、初始诊断、癌症分期信息及生活质量（意大利UCLA前列腺癌指数；SF-12量表）在内的基线评估。在初始诊断6个月后，将进行第二次评估，以评估患者的健康状况、所接受的治疗及生活质量。在初始诊断12个月后，将进行第三次评估，以评估治疗随访情况及生活质量。第四次、第五次、第六次和第七次评估与第三次类似，将分别在初始诊断24、36、48和60个月后完成，还将包括一份食物频率问卷和老年人身体活动量表。
该研究将提供有关前列腺癌患者生活质量及其随时间相对于所接受治疗的变化情况的信息。
