Rosko Andrew, Birkeland Andrew, Shuman Andrew, Prince Mark, Bradford Carol, Wolf Gregory, Worden Francis, Eisbruch Avraham, Srinivasan Ashok, Wong Ka Kit, Spector Matthew E
Department of Otolaryngology - Head and Neck Surgery, University of Michigan Health Center, Ann Arbor, Michigan.
Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, Michigan.
Head Neck. 2017 May;39(5):980-987. doi: 10.1002/hed.24719. Epub 2017 Feb 25.
The purpose of this study was to evaluate the predictive value of positron emission tomography (PET)-CT in identifying occult nodal metastasis in clinically and radiographically N0 patients with recurrent laryngeal cancer undergoing salvage laryngectomy.
Retrospective review of 46 clinically and radiographically N0 patients with recurrent laryngeal cancer who underwent a PET-CT examination before salvage laryngectomy with neck dissection from January 1, 2002, to December 31, 2014, was performed.
Two patients (16.7%) had true-positive PET-CT results, whereas 10 patients (83.3%) had false-negative scans, 1 patient (2.9%) had a false-positive result and 33 patients (97.1%) had a true-negative PET-CT. The sensitivity of PET-CT was 16.7% (95% confidence interval [CI], 3.5% to 46.0%) with a specificity of 97.1% (95% CI, 83.8% to 99.9%), positive predictive value (PPV) of 66.7% (95% CI, 20.2% to 94.4%), and negative predictive value (NPV) of 76.7% (95% CI, 62.1% to 87.0%).
PET-CT has poor sensitivity and NPV making PET-CT an imperfect predictor of nodal disease in recurrent laryngeal cancer. © 2017 Wiley Periodicals, Inc. Head Neck 39: 980-987, 2017.
本研究旨在评估正电子发射断层扫描（PET）-CT在临床及影像学检查为N0的复发性喉癌患者行挽救性喉切除术前识别隐匿性淋巴结转移的预测价值。
对2002年1月1日至2014年12月31日期间46例临床及影像学检查为N0的复发性喉癌患者进行回顾性分析，这些患者在挽救性喉切除术前接受了PET-CT检查并进行了颈部清扫术。
2例患者（16.7%）PET-CT结果为真阳性，10例患者（83.3%）扫描结果为假阴性，1例患者（2.9%）结果为假阳性，33例患者（97.1%）PET-CT结果为真阴性。PET-CT的敏感性为16.7%（95%置信区间[CI]，3.5%至46.0%），特异性为97.1%（95%CI，83.8%至99.9%），阳性预测值（PPV）为66.7%（95%CI，20.2%至94.4%），阴性预测值（NPV）为76.7%（95%CI，62.1%至87.0%）。
PET-CT的敏感性和NPV较差，使其成为复发性喉癌淋巴结疾病的不完美预测指标。©2017威利期刊公司。头颈外科39：980 - 987，2017。
