Sowder Justin C, Cannon Richard B, Buchmann Luke O, Hunt Jason P, Hitchcock Ying, Lloyd Shane, Grossmann Kenneth F, Monroe Marcus M
Division of Otolaryngology - Head and Neck Surgery, The University of Utah School of Medicine, Salt Lake City, Utah.
The Huntsman Cancer Institute, Salt Lake City, Utah.
Head Neck. 2017 May;39(5):876-880. doi: 10.1002/hed.24679. Epub 2017 Feb 25.
National guidelines support both surgical and radiotherapy (RT) as initial treatment options for early-stage oral cavity squamous cell carcinoma (SCC). There remains limited data evaluating the survival outcomes of RT and the current practice patterns for these lesions.
We conducted a retrospective review of 8274 patients in the Surveillance, Epidemiology, and End Results (SEER) database from 1988 to 2008 with T1 to T2N0M0 oral cavity SCC. Primary outcomes were 5-year overall survival (OS) and disease-specific survival (DSS).
Surgical therapy had significantly improved OS (140 months; p < .001) and DSS (217 months; p < .001) compared to surgery with adjuvant RT (104 and 163 months, respectively) and definitive RT (68 and 136 months, respectively). The use of radiation alone was associated with an increased T classification, hard palate, retromolar trigone primary site lesions, and advanced patient age.
Primary radiation without surgery continues to be used in a subset of early-stage oral cavity SCCs, in which it is associated with decreased OS and DSS. © 2017 Wiley Periodicals, Inc. Head Neck 39: 876-880, 2017.
国家指南支持手术和放射治疗（RT）作为早期口腔鳞状细胞癌（SCC）的初始治疗选择。评估RT生存结果以及这些病变当前治疗模式的数据仍然有限。
我们对1988年至2008年监测、流行病学和最终结果（SEER）数据库中8274例T1至T2N0M0口腔SCC患者进行了回顾性研究。主要结局为5年总生存率（OS）和疾病特异性生存率（DSS）。
与辅助RT（分别为104个月和163个月）和根治性RT（分别为68个月和136个月）相比，手术治疗显著提高了OS（140个月；p <.001）和DSS（217个月；p <.001）。单纯放疗与T分期增加、硬腭、磨牙后三角原发部位病变以及患者年龄较大有关。
对于一部分早期口腔SCC患者，仍继续采用不进行手术的单纯放疗，而这与OS和DSS降低相关。©2017威利期刊公司。《头颈》39: 876 - 880，2017年。
