E-钙黏蛋白黏附组装的早期事件。

Early events in the assembly of E-cadherin adhesions.

作者信息

Biswas Kabir H, Zaidel-Bar Ronen

机构信息

Mechanobiology Institute, National University of Singapore, Singapore.

Mechanobiology Institute, National University of Singapore, Singapore; Department of Biomedical Engineering, National University of Singapore, Singapore.

出版信息

Exp Cell Res. 2017 Sep 1;358(1):14-19. doi: 10.1016/j.yexcr.2017.02.037. Epub 2017 Feb 22.

DOI:10.1016/j.yexcr.2017.02.037

PMID:28237244

Abstract

E-cadherin is a calcium dependent cell adhesion molecule that is key to the organization of cells in the epithelial tissue. It is a multidomain, trans-membrane protein in which the extracellular domain forms the homotypic, adhesive interaction while the intracellular domain interacts with the actin cytoskeleton through the catenin family of adaptor proteins. A number of recent studies have provided novel insights into the mechanism of adhesion formation by this class of adhesion proteins. Here, we describe an updated view of the process of E-cadherin adhesion formation with an emphasis on the role of molecular mobility, clustering, and active cellular processes.

摘要

E-钙黏蛋白是一种钙依赖性细胞黏附分子，对于上皮组织中细胞的组织排列至关重要。它是一种多结构域跨膜蛋白，其细胞外结构域形成同型黏附相互作用，而细胞内结构域则通过连环蛋白家族的衔接蛋白与肌动蛋白细胞骨架相互作用。最近的一些研究为这类黏附蛋白形成黏附的机制提供了新的见解。在这里，我们描述了E-钙黏蛋白黏附形成过程的最新观点，重点强调了分子流动性、聚集以及活跃细胞过程的作用。