Domi Trish, Vossough Arastoo, Stence Nicholas V, Felling Ryan J, Leung Jackie, Krishnan Pradeep, Watson Christopher G, Grant P Ellen, Kassner Andrea
Department of Physiology, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Experimental Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania.
Pediatr Neurol. 2017 Apr;69:24-36. doi: 10.1016/j.pediatrneurol.2016.12.015. Epub 2017 Jan 24.
This article was written to provide clinicians and researchers with an overview of a number of advanced neuroimaging techniques in an effort to promote increased utility and the design of future studies using advanced neuroimaging in childhood stroke. The current capabilities of advanced magnetic resonance imaging techniques provide the opportunity to build on our knowledge of the consequences of stroke on the developing brain. These capabilities include providing information about the physiology, metabolism, structure, and function of the brain that are not routinely evaluated in the clinical setting.
During the Proceedings of the Stroke Imaging Laboratory for Children Workshop in Toronto in June 2015, a subgroup of clinicians and imaging researchers discussed how the application of advanced neuroimaging techniques could further our understanding of the mechanisms of stroke injury and repair in the pediatric population. This subgroup was established based on their interest and commitment to design collaborative, advanced neuroimaging studies in the pediatric stroke population.
In working toward this goal, we first sought to describe here the magnetic resonance imaging techniques that are currently available for use, and how they have been applied in other stroke populations (e.g., adult and perinatal stroke).
With the continued improvement in advanced neuroimaging techniques, including shorter acquisition times, there is an opportunity to apply these techniques to their full potential in the research setting and learn more about the effects of stroke in the developing brain.
撰写本文旨在为临床医生和研究人员提供一些先进神经成像技术的概述，以促进这些技术在儿童卒中中的更多应用，并推动未来使用先进神经成像技术开展研究的设计。先进磁共振成像技术的当前能力为我们增进对卒中对发育中大脑影响的认识提供了契机。这些能力包括提供有关大脑生理、代谢、结构和功能的信息，而这些信息在临床环境中并非常规评估内容。
在2015年6月于多伦多举行的儿童卒中成像实验室研讨会上，一组临床医生和成像研究人员讨论了先进神经成像技术的应用如何能进一步加深我们对儿科人群卒中损伤和修复机制的理解。该小组是基于他们对设计儿科卒中人群协作性先进神经成像研究的兴趣和承诺而组建的。
为实现这一目标，我们首先在此力求描述当前可用的磁共振成像技术，以及它们在其他卒中人群（如成人和围产期卒中）中的应用情况。
随着先进神经成像技术的持续改进，包括采集时间缩短，有机会在研究环境中充分发挥这些技术的潜力，并更多地了解卒中对发育中大脑的影响。
