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质子治疗计划中固定装置的水等效厚度——通过多层电离室测量在治疗计划时进行建模及验证

Water equivalent thickness of immobilization devices in proton therapy planning - Modelling at treatment planning and validation by measurements with a multi-layer ionization chamber.

作者信息

Fellin Francesco, Righetto Roberto, Fava Giovanni, Trevisan Diego, Amelio Dante, Farace Paolo

机构信息

Proton Therapy Unit, Hospital of Trento, Azienda Provinciale per i Servizi Sanitari (APSS), Trento, Italy.

Medical Physics Department, Hospital of Trento, Azienda Provinciale per i Servizi Sanitari (APSS), Trento, Italy.

出版信息

Phys Med. 2017 Mar;35:31-38. doi: 10.1016/j.ejmp.2017.02.010. Epub 2017 Feb 23.

Abstract

PURPOSE

To investigate the range errors made in treatment planning due to the presence of the immobilization devices along the proton beam path.

METHODS

The measured water equivalent thickness (WET) of selected devices was measured by a high-energy spot and a multi-layer ionization chamber and compared with that predicted by treatment planning system (TPS). Two treatment couches, two thermoplastic masks (both un-stretched and stretched) and one headrest were selected. At TPS, every immobilization device was modelled as being part of the patient. The following parameters were assessed: CT acquisition protocol, dose-calculation grid-sizes (1.5 and 3.0mm) and beam-entrance with respect to the devices (coplanar and non-coplanar). Finally, the potential errors produced by a wrong manual separation between treatment couch and the CT table (not present during treatment) were investigated.

RESULTS

In the thermoplastic mask, there was a clear effect due to beam entrance, a moderate effect due to the CT protocols and almost no effect due to TPS grid-size, with 1mm errors observed only when thick un-stretched portions were crossed by non-coplanar beams. In the treatment couches the WET errors were negligible (<0.3mm) regardless of the grid-size and CT protocol. The potential range errors produced in the manual separation between treatment couch and CT table were small with 1.5mm grid-size, but could be >0.5mm with a 3.0mm grid-size. In the headrest, WET errors were negligible (0.2mm).

CONCLUSIONS

With only one exception (un-stretched mask, non-coplanar beams), the WET of all the immobilization devices was properly modelled by the TPS.

摘要

目的

研究质子束路径上存在固定装置时治疗计划中产生的射程误差。

方法

使用高能点和多层电离室测量所选装置的测量水等效厚度(WET),并与治疗计划系统(TPS)预测的厚度进行比较。选择了两张治疗床、两个热塑性面罩(未拉伸和拉伸的)和一个头枕。在TPS中,每个固定装置都被建模为患者的一部分。评估了以下参数:CT采集协议、剂量计算网格大小(1.5和3.0毫米)以及相对于装置的射束入口(共面和非共面)。最后,研究了治疗床与CT检查床之间手动分离错误(治疗期间不存在)产生的潜在误差。

结果

在热塑性面罩中,射束入口有明显影响,CT协议有中等影响,TPS网格大小几乎没有影响,只有当非共面射束穿过厚的未拉伸部分时才观察到1毫米的误差。在治疗床中,无论网格大小和CT协议如何,WET误差都可以忽略不计(<0.3毫米)。治疗床与CT检查床之间手动分离产生的潜在射程误差在1.5毫米网格大小时较小,但在3.0毫米网格大小时可能>0.5毫米。在头枕中,WET误差可以忽略不计(0.2毫米)。

结论

除了一个例外(未拉伸的面罩,非共面射束),TPS对所有固定装置的WET都进行了正确建模。

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