Duggar William Neil, Nguyen Alex, Stanford Jason, Morris Bart, Yang Claus C
Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS.
Ironwood Cancer and Research Center, Chandler, AZ.
Med Dosim. 2016 Spring;41(1):34-41. doi: 10.1016/j.meddos.2015.07.001. Epub 2015 Sep 2.
This study is to demonstrate the importance and a method of properly modeling the treatment couch for dose calculation in patient treatment using arc therapy. The 2 treatment couch tops-Aktina AK550 and Elekta iBEAM evo-of Elekta LINACs were scanned using Philips Brilliance Big Bore CT Simulator. Various parts of the couch tops were contoured, and their densities were measured and recorded on the Pinnacle treatment planning system (TPS) using the established computed tomography density table. These contours were saved as organ models to be placed beneath the patient during planning. Relative attenuation measurements were performed following procedures outlined by TG-176 as well as absolute dose comparison of static fields of 10 × 10 cm(2) that were delivered through the couch tops with that calculated in the TPS with the couch models. A total of 10 random arc therapy treatment plans (5 volumetric-modulated arc therapy [VMAT] and 5 stereotactic body radiation therapy [SBRT]), using 24 beams, were selected for this study. All selected plans were calculated with and without couch modeling. Each beam was evaluated using the Delta(4) dosimetry system (Delta(4)). The Student t-test was used to determine statistical significance. Independent reviews were exploited as per the Imaging and Radiation Oncology Core head and neck credentialing phantom. The selected plans were calculated on the actual patient anatomies with and without couch modeling to determine potential clinical effects. Large relative beam attenuations were noted dependent on which part of the couch top beams were passing through. Substantial improvements were also noted for static fields both calculated with the TPS and delivered physically when the couch models were included in the calculation. A statistically significant increase in agreement was noted for dose difference, distance to agreement, and γ-analysis with the Delta(4) on VMAT and SBRT plans. A credentialing review showed improvement in treatment delivery after couch modeling with both thermoluminescent dosimeter doses and film analysis. Furthermore, analysis of treatment plans with and without using the couch model showed a statistically significant reduction in planning target volume coverage and increase in skin dose. In conclusion, ignoring the treatment couch, a common practice when generating a patient treatment plan, can overestimate the dose delivered especially for arc therapy. This work shows that explicitly modeling the couch during planning can meaningfully improve the agreement between calculated and measured dose distributions. Because of this project, we have implemented the couch models clinically across all treatment plans.
本研究旨在证明在使用弧形治疗的患者治疗中,正确构建治疗床模型以进行剂量计算的重要性及方法。使用飞利浦Brilliance大孔径CT模拟器对Elekta直线加速器的两种治疗床面——Aktina AK550和Elekta iBEAM evo进行扫描。对床面的各个部分进行轮廓勾画,并使用已建立的计算机断层扫描密度表在Pinnacle治疗计划系统(TPS)上测量并记录其密度。这些轮廓被保存为器官模型,以便在计划过程中放置在患者下方。按照TG - 176概述的程序进行相对衰减测量,以及对通过床面的10×10 cm²静态野的绝对剂量进行比较,即将通过床面实际照射的剂量与在TPS中使用床模型计算出的剂量进行比较。本研究共选择了10个随机弧形治疗计划(5个容积调强弧形治疗[VMAT]和5个立体定向体部放射治疗[SBRT]),使用24个射束。所有选定的计划均在有和没有床模型的情况下进行计算。每个射束使用Delta(4)剂量测定系统(Delta(4))进行评估。使用学生t检验来确定统计学显著性。根据影像和放射肿瘤学核心头颈认证体模进行独立评估。选定的计划在有和没有床模型的情况下,根据实际患者解剖结构进行计算,以确定潜在的临床效果。注意到射束通过床面的不同部位时,相对射束衰减差异很大。当在计算中包含床模型时,对于TPS计算的静态野以及实际物理照射的静态野,都观察到了显著改善。对于VMAT和SBRT计划,在剂量差异、一致性距离和使用Delta(4)进行的γ分析方面,一致性有统计学显著提高。认证评估表明,在使用热释光剂量计剂量和胶片分析进行床建模后,治疗实施有了改善。此外,对使用和不使用床模型的治疗计划进行分析表明,计划靶体积覆盖率有统计学显著降低,皮肤剂量增加。总之,在生成患者治疗计划时常见的忽略治疗床的做法,可能会高估所给予的剂量,尤其是对于弧形治疗。这项工作表明,在计划过程中明确构建床模型可以显著提高计算剂量分布与测量剂量分布之间的一致性。由于这个项目,我们已经在临床上对所有治疗计划实施了床模型。