泰勒氏鼠脑脊髓炎病毒感染SJL/J和C57BL/6J小鼠：多发性硬化症和癫痫的模型
Theiler's murine encephalomyelitis virus infection of SJL/J and C57BL/6J mice: Models for multiple sclerosis and epilepsy.
作者信息
DePaula-Silva Ana Beatriz, Hanak Tyler J, Libbey Jane E, Fujinami Robert S
机构信息
Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT 84112, USA.
Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT 84112, USA.
出版信息
J Neuroimmunol. 2017 Jul 15;308:30-42. doi: 10.1016/j.jneuroim.2017.02.012. Epub 2017 Feb 12.
Abstract
Mouse models are great tools to study the mechanisms of disease development. Theiler's murine encephalomyelitis virus is used in two distinct viral infection mouse models to study the human diseases multiple sclerosis (MS) and epilepsy. Intracerebral (i.c.) infection of the SJL/J mouse strain results in persistent viral infection of the central nervous system and a MS-like disease, while i.c. infection of the C57BL/6J mouse strain results in acute seizures and epilepsy. Our understanding of how the immune system contributes to the development of two disparate diseases caused by the same virus is presented.
摘要
小鼠模型是研究疾病发展机制的优秀工具。泰勒氏鼠脑脊髓炎病毒被用于两种不同的病毒感染小鼠模型，以研究人类疾病多发性硬化症（MS）和癫痫。将SJL/J小鼠品系进行脑内（i.c.）感染会导致中枢神经系统的持续性病毒感染和类似MS的疾病，而将C57BL/6J小鼠品系进行脑内感染则会导致急性癫痫发作和癫痫。本文介绍了我们对免疫系统如何促成由同一种病毒引起的两种不同疾病发展的理解。
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