See Hoe Louise, Patel Hemal H, Peart Jason N
Menzies Health Institute Queensland, Griffith University, Southport, QLD, 4222, Australia.
Critical Care Research Group, The Prince Charles Hospital and The University of Queensland, Chermside, QLD, Australia.
Handb Exp Pharmacol. 2018;247:301-334. doi: 10.1007/164_2017_6.
The opioid receptor family, with associated endogenous ligands, has numerous roles throughout the body. Moreover, the delta opioid receptor (DORs) has various integrated roles within the physiological systems, including the cardiovascular system. While DORs are important modulators of cardiovascular autonomic balance, they are well-established contributors to cardioprotective mechanisms. Both endogenous and exogenous opioids acting upon DORs have roles in myocardial hibernation and protection against ischaemia-reperfusion (I-R) injury. Downstream signalling mechanisms governing protective responses alternate, depending on the timing and duration of DOR activation. The following review describes models and mechanisms of DOR-mediated cardioprotection, the impact of co-morbidities and challenges for clinical translation.
阿片受体家族及其相关的内源性配体在全身发挥着众多作用。此外，δ阿片受体（DORs）在生理系统中具有多种综合作用，包括心血管系统。虽然DORs是心血管自主平衡的重要调节因子，但它们也是心脏保护机制的既定贡献者。作用于DORs的内源性和外源性阿片类药物在心肌冬眠和抗缺血再灌注（I-R）损伤中都发挥着作用。取决于DOR激活的时间和持续时间，控制保护反应的下游信号机制会有所不同。以下综述描述了DOR介导的心脏保护的模型和机制、合并症的影响以及临床转化面临的挑战。
