Ito Satoru, Uchida Akemi, Isobe Yoshitaka, Hasegawa Yoshinori
Department of Respiratory Medicine, Nagoya University School of Medicine, Nagoya 466-8550, Japan.
Clinical Laboratory, Nagoya University Hospital, Nagoya 466-8550, Japan.
Respir Physiol Neurobiol. 2017 Jun;240:41-47. doi: 10.1016/j.resp.2017.02.012. Epub 2017 Feb 24.
The aim of this retrospective study was to assess responses to a bronchodilator by forced oscillation technique (FOT) and to relate the results of respiratory impedance (Zrs) to spirometric parameters in patients with chronic obstructive pulmonary disease (COPD). Zrs was measured as a function of frequency from 4 to 36Hz before and after inhalation of procaterol, a short-acting β-agonist (n=60). Respiratory resistance (Rrs) and reactance (Xrs) were significantly frequency-dependent, and inspiratory and expiratory phases were different both before and after procaterol inhalation. The Rrs at 4Hz and Xrs at 4-20Hz during a whole breath were significantly improved after procaterol inhalation. The response to procaterol inhalation varied among patients, and changes in Xrs at 4Hz significantly correlated with% change in forced expiratory volume in one second and changes in forced vital capacity. Taken together, Zrs, and specifically Xrs parameters, are sensitive to acute physiological responses to a bronchodilator in COPD.
这项回顾性研究的目的是通过强迫振荡技术（FOT）评估慢性阻塞性肺疾病（COPD）患者对支气管扩张剂的反应，并将呼吸阻抗（Zrs）结果与肺量计参数相关联。在吸入短效β受体激动剂丙卡特罗前后（n = 60），测量4至36Hz频率范围内的Zrs。呼吸阻力（Rrs）和电抗（Xrs）显著依赖于频率，并且在丙卡特罗吸入前后吸气和呼气阶段均有所不同。吸入丙卡特罗后，全呼吸过程中4Hz时的Rrs和4至20Hz时的Xrs显著改善。患者对丙卡特罗吸入的反应各不相同，4Hz时Xrs的变化与一秒用力呼气量的百分比变化和用力肺活量的变化显著相关。总之，Zrs，特别是Xrs参数，对COPD患者支气管扩张剂的急性生理反应敏感。
