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急性肾损伤与肾脏恢复:急性疾病质量倡议(ADQI)16 工作组的共识报告。

Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup.

机构信息

Department of Medicine, Veterans Affairs Medical Center, Washington DC, USA.

Australian and New Zealand Intensive Care Research Centre, Monash University, Australia.

出版信息

Nat Rev Nephrol. 2017 Apr;13(4):241-257. doi: 10.1038/nrneph.2017.2. Epub 2017 Feb 27.

Abstract

Consensus definitions have been reached for both acute kidney injury (AKI) and chronic kidney disease (CKD) and these definitions are now routinely used in research and clinical practice. The KDIGO guideline defines AKI as an abrupt decrease in kidney function occurring over 7 days or less, whereas CKD is defined by the persistence of kidney disease for a period of >90 days. AKI and CKD are increasingly recognized as related entities and in some instances probably represent a continuum of the disease process. For patients in whom pathophysiologic processes are ongoing, the term acute kidney disease (AKD) has been proposed to define the course of disease after AKI; however, definitions of AKD and strategies for the management of patients with AKD are not currently available. In this consensus statement, the Acute Disease Quality Initiative (ADQI) proposes definitions, staging criteria for AKD, and strategies for the management of affected patients. We also make recommendations for areas of future research, which aim to improve understanding of the underlying processes and improve outcomes for patients with AKD.

摘要

已经就急性肾损伤 (AKI) 和慢性肾脏病 (CKD) 达成了共识定义,这些定义现在在研究和临床实践中被常规使用。KDIGO 指南将 AKI 定义为肾功能在 7 天或更短时间内突然下降,而 CKD 则定义为肾脏疾病持续时间超过 90 天。AKI 和 CKD 越来越被认为是相关的实体,在某些情况下,它们可能代表疾病过程的连续体。对于那些生理过程仍在进行的患者,已经提出了急性肾损伤后疾病过程的术语“急性肾疾病 (AKD)”来定义;然而,目前尚无 AKD 的定义和 AKD 患者管理策略。在本共识声明中,急性疾病质量倡议 (ADQI) 提出了 AKD 的定义、分期标准以及对受影响患者的管理策略。我们还为未来的研究领域提出了建议,旨在加深对潜在过程的理解并改善 AKD 患者的预后。

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