双膦酸盐相关颌骨骨坏死的治疗——7例报告
Treatment of bisphosphonate-related osteonecrosis of the jaws - a report of seven cases.
作者信息
Jakiel Joanna, Rahnama Mansur, Szczerba-Gwóźdź Joanna
机构信息
Oral Surgery Department, Medical University of Lublin, Poland.
出版信息
Contemp Oncol (Pozn). 2016;20(6):486-490. doi: 10.5114/wo.2016.65610. Epub 2017 Jan 12.
AIM OF THE STUDY
The aim of the study was to report on seven cases of BRONJ treated with surgical debridement, oral antibiotics and gentamicin-collagen sponge (Collatamp EG) placed in the bone wound.
MATERIAL AND METHODS
Seven patients with 9 sites of BRONJ stage 2 were included in the study. Perioperative oral antibiotics, surgical debridement and/or sequestrotomy and gentamicin-collagen sponge (Collatamp EG) were used. Postoperative monitoring was carried out for the next 3 months.
RESULTS
Three weeks after the surgery, six sites of BRONJ in five patients were treated successfully. In two patients on three sites BRONJ stage 1 was observed. Three months after surgery another two sites healed fully. In one patient there was still BRONJ stage 1, however, the area of exposed bone was visibly reduced.
CONCLUSIONS
The use of surgical debridement together with oral antibiotic therapy and collagen-gentamycin sponge indicates positive results regarding the surgical treatment of BRONJ.
研究目的
本研究旨在报告7例采用手术清创、口服抗生素以及在骨创口中放置庆大霉素胶原蛋白海绵（Collatamp EG）治疗的放射性骨坏死性颌骨骨髓炎（BRONJ）病例。
材料与方法
本研究纳入了7例患有9处2期BRONJ的患者。采用围手术期口服抗生素、手术清创和/或死骨切除术以及庆大霉素胶原蛋白海绵（Collatamp EG）。术后接下来的3个月进行监测。
结果
术后3周，5例患者的6处BRONJ得到成功治疗。在2例患者的3处观察到1期BRONJ。术后3个月，另外2处完全愈合。1例患者仍为1期BRONJ，然而，暴露骨的面积明显减小。
结论
手术清创联合口服抗生素治疗以及胶原蛋白-庆大霉素海绵表明在BRONJ的手术治疗方面取得了积极成果。
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