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曲安奈德浸渍鼻填塞物在内镜鼻窦手术中的应用:我们的经验

Triamcinolone Impregnated Nasal Pack in Endoscopic Sinus Surgery: Our Experience.

作者信息

Sabarinath V, Harish M R, Divakaran Shilpa

机构信息

Sri Manakula Vinayagar Medical College and Hospital, Madagadipet, Puducherry India.

Pondicherry Institute of Medical Sciences, Kalapet, Puducherry India.

出版信息

Indian J Otolaryngol Head Neck Surg. 2017 Mar;69(1):88-92. doi: 10.1007/s12070-016-1041-x. Epub 2017 Jan 11.

Abstract

The selection of an effective packing method to prevent postoperative complications and recurrence following Endoscopic Sinus Surgery remains ambiguous at present. This study was conducted to evaluate the efficacy of Triamcinolone impregnated nasal pack in Endoscopic Sinus Surgery, in the prevention of postoperative crusting, edema, infection and recurrence. This study was an interventional randomized placebo-controlled study, conducted at a tertiary care centre in South India between February 2015 and May 2016, after getting approval from Institute Ethical Committee. 75 patients with bilateral chronic rhinosinusitis undergoing Endoscopic Sinus Surgery were selected for the study. After surgery, each patient was randomized to receive Polyvinyl Acetal (Merocel) nasal pack soaked with Triamcinolone to one side, while the contralateral side was packed with Merocel soaked with saline. Incidence of postoperative crusting, edema, polypoidal change and mucosal discharge was evaluated using the Endoscopic Staging System at 1st and 2nd weeks and at 1st and 3rd months of surgery. A significant reduction in mucosal edema was observed in the test group at all stages of follow up ( values <0.05). Incidence of crusting was found to be significantly lower in the test group ( values <0.05) except at 3 months ( value >0.05). However, there was no significant difference in the occurrence of polypoidal change and mucosal discharge between the groups. Triamcinolone impregnated nasal pack is an effective method to reduce the incidence of early postoperative complications following Endoscopic Sinus Surgery.

摘要

目前,选择一种有效的填塞方法以预防鼻内镜鼻窦手术后的并发症和复发仍不明确。本研究旨在评估曲安奈德浸渍鼻填塞物在鼻内镜鼻窦手术中预防术后结痂、水肿、感染和复发的疗效。本研究是一项干预性随机安慰剂对照研究,于2015年2月至2016年5月在印度南部的一家三级医疗中心进行,研究获得了机构伦理委员会的批准。选择75例接受鼻内镜鼻窦手术的双侧慢性鼻窦炎患者进行研究。术后,每位患者被随机分配,一侧接受用曲安奈德浸泡的聚乙烯醇缩醛(Merocel)鼻填塞物,而另一侧用盐水浸泡的Merocel进行填塞。在术后第1周和第2周以及手术第1个月和第3个月,使用内镜分期系统评估术后结痂、水肿、息肉样改变和黏膜分泌物的发生率。在所有随访阶段,试验组的黏膜水肿均显著减轻(P值<0.05)。除3个月时(P值>0.05)外,试验组的结痂发生率显著较低(P值<0.05)。然而,两组之间息肉样改变和黏膜分泌物的发生率没有显著差异。曲安奈德浸渍鼻填塞物是一种有效降低鼻内镜鼻窦手术后早期并发症发生率的方法。

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