Gundogdu Ramazan, Hergovich Alexander
Tumour Suppressor Signaling Networks Laboratory, UCL Cancer Institute, University College London, UK.
J Cell Signal (Los Angel). 2016 Sep 6;1:125.
This article is the authors' opinion of the roles of the signal transducer Mps one binder 2 (MOB2) in the control of cell cycle progression and the DNA Damage Response (DDR). We recently found that endogenous MOB2 is required to prevent the accumulation of endogenous DNA damage in order to prevent the undesired, and possibly detrimental, activation of cell cycle checkpoints. In this regard, it is noteworthy that MOB2 has been linked biochemically to the regulation of the NDR1/2 (aka STK38/STK38L) protein kinases, which themselves have functions at different steps of the cell cycle. Therefore, we are speculating in this article about the possible connections of MOB2 with NDR1/2 kinases in cell cycle and DDR Signaling.
本文是作者对信号转导子Mps单结合蛋白2（MOB2）在细胞周期进程控制和DNA损伤反应（DDR）中作用的观点。我们最近发现，内源性MOB2是防止内源性DNA损伤积累所必需的，以防止细胞周期检查点出现意外的、可能有害的激活。在这方面，值得注意的是，MOB2在生化上与NDR1/2（又名STK38/STK38L）蛋白激酶的调节有关，而NDR1/2蛋白激酶本身在细胞周期的不同阶段发挥作用。因此，我们在本文中推测MOB2与NDR1/2激酶在细胞周期和DDR信号传导中的可能联系。
