Dooley D J, Jones G H, Robbins T W
Gödecke Research Institute, Freiburg, F.R.G.
Brain Res. 1987 Sep 8;420(1):152-6. doi: 10.1016/0006-8993(87)90251-4.
A 6-hydroxydopamine-induced lesion of the dorsal noradrenergic bundle (DNB) in rats markedly decreased neocortical noradrenaline concentration (NNC) by 72-100% as measured 1, 3 and 13 months after the lesioning procedure. The concomitant assessment of neocortical alpha 2- and beta 1-adrenoceptor binding (NAAB and NBAB, respectively) usually indicated significant increases of 25-72% for these two variables. There were, however, cases of unchanged NAAB and NBAB which presumably reflected an incomplete DNB lesion and a consequent time-related, partial recovery of NNC. The results emphasize the potential for long-term sequelae of the DNB lesion, and the existence of a critical NNC threshold (approximately 10-30% of control NNC values) which modulates postsynaptic alpha 2- and beta 1-adrenoceptor density.
在大鼠中，6-羟基多巴胺诱导的背侧去甲肾上腺素能束（DNB）损伤，在损伤手术后1、3和13个月测量时，显著降低了新皮质去甲肾上腺素浓度（NNC），降幅达72%-100%。对新皮质α2-和β1-肾上腺素能受体结合（分别为NAAB和NBAB）的同步评估通常表明，这两个变量显著增加了25%-72%。然而，存在NAAB和NBAB未改变的情况，这可能反映了DNB损伤不完全，以及随后与时间相关的NNC部分恢复。结果强调了DNB损伤长期后遗症的可能性，以及存在一个关键的NNC阈值（约为对照NNC值的10%-30%），该阈值调节突触后α2-和β1-肾上腺素能受体密度。
