Vasin M V, Ushakov I B, Kovtun V Yu, Komarova S N, Semenova L A, Galkin A A, Afanas'ev R V, Bukhtiyarov I V
Research Institute of Occupational Medicine, Russian Academy of Sciences, Moscow, Russia.
Research and Development Center "Farmzaschita", the Federal Medical-Biological Agency of Russia, Khimki, Moscow Region, Russia.
Bull Exp Biol Med. 2017 Feb;162(4):466-469. doi: 10.1007/s10517-017-3641-1. Epub 2017 Feb 27.
The therapeutic radiomitigating effect of cystamine and indralin was studied in experiments on mice and rats and pharmacological analysis of these drugs was carried out. The animals were subjected to whole-body Co γ-irradiation. The mice were exposed to single (9-10 Gy) or double (8 Gy) irradiation with an interval of 1 month. The rats were exposed to 10 Gy with partial shielding of the upper quarter of the abdomen. In experiments on mice, pretreatment with reserpine abolished the therapeutic effect of cystamine administered repeatedly every 15 min over 1 h after irradiation. Moreover, summation of the radioprotective and therapeutic effects of the radioprotector was revealed under these conditions. In mice and rats, α-adrenoreceptor blocker terazosin did not abolish the therapeutic effect of indralin administrated after irradiation, but blocked the radioprotective effect of indralin applied prior to irradiation. At the same time, 5-HT serotonin receptor blocker tropoxin abolished the therapeutic effect of indralin without affecting its radioprotective activity.
在小鼠和大鼠实验中研究了半胱胺和吲哒胺的放射缓解治疗作用，并对这些药物进行了药理学分析。动物接受全身钴γ射线照射。小鼠接受单次（9 - 10 Gy）或两次（8 Gy）照射，间隔1个月。大鼠接受10 Gy照射，同时对腹部上四分之一进行部分屏蔽。在小鼠实验中，用利血平预处理消除了照射后1小时内每15分钟重复给药的半胱胺的治疗效果。此外，在这些条件下还发现了放射防护剂的放射防护和治疗效果的叠加。在小鼠和大鼠中，α - 肾上腺素能受体阻滞剂特拉唑嗪并未消除照射后给予的吲哒胺的治疗效果，但阻断了照射前应用的吲哒胺的放射防护效果。同时，5 - HT 5 - 羟色胺受体阻滞剂托普西汀消除了吲哒胺的治疗效果，而不影响其放射防护活性。
