Vasin M V, Ushakov I B, Antipov V V
State Scientific Centre Institute of Medical and Biological Problems, Russian Academy of Sciences, Moscow, Russia.
Bull Exp Biol Med. 2015 Sep;159(5):597-600. doi: 10.1007/s10517-015-3022-6. Epub 2015 Oct 13.
Involvement of hormonal response (catecholamine release) to acute hypoxia induced by radioprotectors in modification of their radioprotective properties was studied in experiments on outbred mature female albino mice, female albino rats, and dogs of both sexes. The response intensity was evaluated by the reduction of radioprotective and toxic properties of indralin (a α1-adrenoceptor agonist and a radioprotector). The radioprotective effect of indralin was measured using lethal doses of whole-body γ-irradiation ((60)Co) and its acute toxicity was assessed by LD50. It was found that repeated administration of indralin with 30-60-min intervals was followed by weakening of its radioprotective effect. Similar sensitization effect of indralin was observed after pretreatment with cystamine and epinephrine. Comparison of the severity of sensitization after administration of epinephrine and cystamine in the dose providing radioprotective effect showed that the potential aminothiol-induced release of catecholamines can provide optimal long-term radioprotective effect of epinephrine.
在远交系成年雌性白化小鼠、雌性白化大鼠以及雌雄两性犬的实验中，研究了激素反应（儿茶酚胺释放）对辐射防护剂诱导的急性低氧的参与在改变其辐射防护特性方面的作用。通过降低因得拉林（一种α1 -肾上腺素能受体激动剂和辐射防护剂）的辐射防护和毒性特性来评估反应强度。使用全身γ射线致死剂量（(60)Co）测量因得拉林的辐射防护效果，并通过半数致死量评估其急性毒性。发现以30 - 60分钟的间隔重复给予因得拉林后，其辐射防护效果减弱。在用半胱胺和肾上腺素预处理后，观察到因得拉林有类似的致敏作用。比较给予具有辐射防护效果剂量的肾上腺素和半胱胺后的致敏严重程度表明，潜在的氨基硫醇诱导的儿茶酚胺释放可提供肾上腺素最佳的长期辐射防护效果。
