巴西人群中非黑色素瘤皮肤癌中默克尔细胞多瘤病毒的分子流行率
Molecular prevalence of Merkel cell polyomavirus in nonmelanoma skin cancer in a Brazilian population.
作者信息
Bellott T R, Baez C F, Almeida S G, Venceslau M T, Zalis M G, Guimarães M A, Rochael M C, Luz F B, Varella R B, Almeida J R
机构信息
Department of Clinical Medicine, Universidade Federal Fluminense, Hospital Universitário Antônio Pedro, Niterói, Rio de Janeiro, Brazil.
Department of Preventive Medicine, Universidade Federal do Rio do Janeiro, Brazil.
出版信息
Clin Exp Dermatol. 2017 Jun;42(4):390-394. doi: 10.1111/ced.13069. Epub 2017 Feb 27.
BACKGROUND
Merkel cell polyomavirus (MCPyV), a newly described oncogenic virus, has been found in association with tumours other than Merkel cell carcinoma (MCC). As yet, little is known about the involvement or influence of MCPyV on the development of these tumours and its prevalence in various populations.
AIM
To assess the prevalence of MCPyV DNA in cases of nonmelanoma skin cancer (NMSC).
METHODS
The prevalence of MCPyV DNA was assessed in 96 cases of NMSC in a Brazilian population comprising 76 subjects, and these results were correlated with epidemiological and demographical data.
RESULTS
MCPyV DNA was detected in 23 of 69 (33.3%) basal cell carcinomas, in 2 of 11 (18%) squamous cell carcinomas, 2 of 4 Bowen disease case, 0 of 1 MCC and 4 of 11 other skin disorders.
CONCLUSION
Despite the frequent detection of MCPyV DNA in NMSC, its possible role in the development of NMSC still needs further investigation.
背景
默克尔细胞多瘤病毒（MCPyV）是一种新发现的致癌病毒，已被发现与默克尔细胞癌（MCC）以外的肿瘤有关。目前，关于MCPyV在这些肿瘤发生过程中的参与情况或影响及其在不同人群中的流行率知之甚少。
目的
评估非黑色素瘤皮肤癌（NMSC）病例中MCPyV DNA的流行率。
方法
在一个由76名受试者组成的巴西人群中，对96例NMSC病例评估MCPyV DNA的流行率，并将这些结果与流行病学和人口统计学数据相关联。
结果
在69例基底细胞癌中的23例（33.3%）、11例鳞状细胞癌中的2例（18%）、4例鲍恩病病例中的2例、1例MCC中的0例以及11例其他皮肤疾病中的4例检测到MCPyV DNA。
结论
尽管在NMSC中经常检测到MCPyV DNA，但其在NMSC发生过程中的可能作用仍需进一步研究。
Zotero 插件