Gopalaiah Kovuru, Saini Anupama, Chandrudu Sankala Naga, Rao Devarapalli Chenna, Yadav Harsh, Kumar Binay
Organic Synthesis and Catalysis Laboratory, Department of Chemistry, University of Delhi, Delhi 110007, India.
Crystal Lab, Department of Physics & Astrophysics, University of Delhi, Delhi 110007, India.
Org Biomol Chem. 2017 Mar 8;15(10):2259-2268. doi: 10.1039/c7ob00122c.
A copper-catalyzed oxidative coupling reaction of o-phenylenediamines with 2-aryl/heteroarylethylamines using molecular oxygen as an oxidant has been developed. This approach provides a practical and direct access to construct quinoxalines in excellent yields at room temperature. The reaction has a broad substrate scope and exhibits excellent functional-group tolerance. This method could be easily scaled up and applied to the synthesis of biologically active molecules bearing a quinoxaline structural scaffold.
已开发出一种以分子氧为氧化剂的铜催化邻苯二胺与2-芳基/杂芳基乙胺的氧化偶联反应。该方法提供了一种在室温下以优异产率构建喹喔啉的实用且直接的途径。该反应具有广泛的底物范围，并表现出优异的官能团耐受性。该方法可以很容易地扩大规模，并应用于具有喹喔啉结构支架的生物活性分子的合成。
